济宁地区自然就诊妇女宫颈HPV感染型别调查及HR-HPV持续性感染危险因素分析  

Investigation on cervical HPV infection type and risk factors of persistent infection of HR-HPV in women of Jining area

作　　者：宫迎迎 周烨[1] 韩辉[1] 张素伟 杜蓓蓓 杨林青[1] GONG Ying-ying;ZHOU Ye;HAN Hui;ZHANG Su-wei;DU Bei-bei;YANG Lin-qing(Department of Gynecology,Affiliated Hospital of Jining Medical University,Jining 272100,P.R.China)

机构地区：[1]济宁医学院附属医院妇科,山东济宁272100

出　　处：《中华肿瘤防治杂志》2020年第21期1698-1702,共5页Chinese Journal of Cancer Prevention and Treatment

基　　金：济宁医学院教师科研扶持基金(JY2017FS004)。

摘　　要：目的人乳头瘤病毒(human papillomavirus,HPV)感染是宫颈癌发生的必要因素,分布具有明显的地域性特征。本研究探讨济宁地区宫颈HPV感染情况及高危人乳头瘤病毒(highrisk-human papillomavirus,HR-HPV)持续感染的关联因素,为本地区宫颈癌防治工作提供依据。方法选取2017-01-01-2018-01-01济宁医学院附属医院门诊或住院行宫颈防癌筛查的11396名女性进行基线调查。采用流行病学问卷调查、宫颈上皮脱落细胞HPV分型及宫颈细胞学TCT检测。分析HPV各型别感染情况,每隔6个月对初次筛查HPV阳性的患者进行2次HPV分型的随访。采用SPSS19.0对数据进行统计学分析。结果11407名女性进行HPV分型检测,排除不合格样品11份,共纳入研究妇女11396名。HPV阳性感染率为24.2%(2762/11396),其中以HPV16(13.7%)最为常见,其次是HPV58(12.7%)、HPV52(11.9%)。HR-HPV感染妇女中HPV持续感染率最高。单因素分析显示,年龄、吸烟史、初次性交年龄、妊娠次数、性生活频率、非避孕套避孕、妇科炎症和同房前无清洗行为是HR-HPV持续性感染的关联因素,P<0.05。多因素分析显示,高年龄(OR=7.949,95%CI为2.614~24.174;OR=3.245,95%CI为1.190~8.846)、多次妊娠(OR=2.909,95%CI为1.248~6.782)、非避孕套同房(OR=0.222,95%CI为0.093~0.530),是HR-HPV持续感染的独立因素。结论济宁地区宫颈HPV感染型别以HPV16最为常见,其次为HPV58、HPV52。无生育要求的女性避孕套同房,加强对高年龄、多次妊娠的HPV感染女性随访并及时就诊,是宫颈癌防治工作的有效措施。OBJECTIVE The incidence of cervical cancer in China are increasing significantly.Human papillomavirus(HPV)infection is essential for cervical cancer.The injection of preventive vaccine has become a popular choice for preventing HPV infection and preventing cervical cancer.However,the HPV infection has obvious regional characteristics.This study aimed to study the HPV infection of the cervix and the related factors of HR-HPV persistent infection in Jining area,and provide an basis for the prevention and treatment of cervical cancer.METHODS From January 01,2017 to January 01,2018,a baseline survey was conducted on 11396 women in the outpatient clinics of the Affiliated Hospital of Jining Medical University or in the hospital for cervical cancer screening,including epidemiological questionnaire,cervical epithelial epithelial HPV typing and cervical cytology TCT detection,and analyzing the infection status of each HPV type.Two follow-up visits of HPV typing were conducted for patients who were initially screened for HPV positive every six months to explore the related factors of HR-HPV persistent infection.RESULTS Totally 11407 women underwent HPV typing,and 11 unqualified samples were excluded.A total of 11396 women were included in the study.Among the 11396 samples,HPV was positive in 2762 cases,and the HPV infection rate was 24.2%(2762/11396),of which HPV-16(13.7%)was the most common,followed by HPV-58(12.7%),HPV52(11.9%).The highest rate of persistent HPV infection among women with multiple high-risk HPV infection,Univariate analysis showed that age,smoking history,first sexual intercourse age,number of pregnancies,frequency of sexual life,non-condom contraception,gynecological inflammation,and no-cleaning behavior before the same room were related factors of persistent infection of HR-HPV(P<0.05).Multivariate analysis showed:Higher age(OR=7.949,95%CI=2.614-24.174;OR=3.245,95%CI=1.190-8.846),multiple pregnancies(OR=2.909,95%CI=1.190-8.846)and non-condom sex(OR=0.222,95%CI=1.248-6.782)were independent factors of p

关 键 词：人乳头瘤病毒 感染型别 持续感染 相关因素 

分 类 号：R711.74[医药卫生—妇产科学]