新生儿红细胞输注阈值及疗效分析  

RBC transfusion threshold and efficacy in neonates

作　　者：付晓艳 张慧敏[1] 王孟键 邱立娟[1] 张帅行 马曙轩[1] FU Xiaoyan;ZHANG Huimin;WANG Mengjian;QIU Lijuan;ZHANG Shuaihang;MA Shuxuan(Department of Blood Transfusion,Beijing Children′s Hospital Affiliated of Capital Medical University,Beijing 100045,China)

机构地区：[1]首都医科大学附属北京儿童医院输血科,北京100045

出　　处：《中国输血杂志》2020年第10期1016-1018,共3页Chinese Journal of Blood Transfusion

摘　　要：目的分析本院新生儿红细胞输注阈值及输注疗效,旨在为新生儿输血提供参考。方法纳入2018年11月1日—2019年10月31日本院进行红细胞输注的新生儿184例。回顾性分析患儿胎龄、性别、出生体重、疾病诊断、输血前后24 h内单位体重血红蛋白变化值(记为△Hb)等结果,并进行统计学分析。结果1)本院184例新生儿输注阈值为83.00(77.00,101.75g/L;2)极低体重组输注阈值91.50(80.00,104.50)、低体重组输注阈值90.00(76.25,109.75)高于正常体重组81.00(72.00,92.00);3)新生儿溶血病组输注阈值77.00(64.00,81.50)明显低于其他疾病组,而新生儿坏死性小肠结肠炎组95.00(79.50,110.00)和新生儿呼吸窘迫综合征组输注阈值99.00(84.00,112.00)高于其他疾病组;4)早产儿组输注红细胞后△Hb 14.17(8.10,20.39)高于足月儿组10.23(7.13,14.05);极低体重组输注红细胞后△Hb 13.17(8.98,22.86)、低体重组△Hb 14.85(7.80,20.39)高于正常体重组10.49(7.06,14.24),以上差异均为P<0.05。结论本院新生儿输注阈值为83.00(77.00,101.75)g/L,输注阈值主要与新生儿出生体重和疾病诊断有关,输注疗效受患儿胎龄和出生体重影响,但与输注的红细胞成分无关。Objective To analyze the RBC infusion threshold and efficiency in neonates in our hospital,thus providing references for neonatal blood transfusion.Methods A total of 184 neonates who received RBC transfusion from November 1,2018 to October 31,2019 in our hospital were enrolled.The clinical data of gestational age,gender,birth weight,disease diagnosis,hemoglobin changes per unit body weight(recorded as△Hb)within 24 h before and after transfusion were analyzed retrospectively.Results 1)The RBC infusion threshold in neonates in our hospital was 83.00(77.00,101.75)g/L.2)The threshold of extremely low birth weight group and low birth weight was 91.50(80.00,104.50)and 90.00(76.25,109.75),which were higher than 81.00(72.00,92.00)of normal birth weight group.3)The infusion threshold of neonatal hemolytic disease group was 77.00(64.00,81.50),which was significantly lower than that of other groups.However,the infusion threshold of necrotizing enterocolitis group and neonatal respiratory distress syndrome group was 95.00(79.50,110.00)and 99.00(84.00,112.00),respectively,which were higher than that of other groups.4)The△Hb value 14.17(8.10,20.39)after transfusion in premature infants group was higher than 10.23(7.13,14.05)in term infant group.The△Hb value in extremely low birth weight group and low birth weight group were 13.17(8.98,22.86)and14.85(7.80,20.39),which were higher than 10.49(7.06,14.24)in normal birth weight group.The differences above were statistically significant(P<0.05).Conclusion The erythrocyte infusion threshold,mainly related to the birth weight and disease diagnosis,is 83.00(77.00101.75)g/L in neonates in our hospital.The efficacy of transfusion is affected by gestational age and birth weight,but not by RBC preparations,.

关 键 词：新生儿 足月儿 早产儿 输注阈值 

分 类 号：R457.1[医药卫生—治疗学] R722.1[医药卫生—临床医学]