丙种球蛋白联合阿司匹林对川崎病患儿外周血Treg细胞、淋巴细胞的影响  

Effect of gamma globulin combined with aspirin on peripheral blood Treg cells and lymphocytes in children with Kawasaki disease

作　　者：王婉霞[1] 刘媛 梅玲华 WANG Wan-xia;LIU Yuan;MEI Ling-hua(Quality Control Section,the Second Hospital of Yulin City,Yulin 719000,Shaanxi,CHINA;Department of Pediatrics,the Second Hospital of Yulin City,Yulin 719000,Shaanxi,CHINA)

机构地区：[1]榆林市第二医院质量控制科,陕西榆林719000 [2]榆林市第二医院儿科,陕西榆林719000

出　　处：《海南医学》2020年第24期3170-3173,共4页Hainan Medical Journal

摘　　要：目的研究丙种球蛋白联合阿司匹林对川崎病患儿外周血调节T(Treg)细胞、淋巴细胞的影响,为临床治疗提供指导。方法选取2017年1月至2020年2月榆林市第二医院收治的96例川崎病患儿进行研究,按照随机数表法分为观察组和对照组,每组48例。对照组单独应用丙种球蛋白治疗,观察组采用丙种球蛋白联合阿司匹林治疗,两组患儿均治疗2个月。比较两组患儿临床症状消失时间、治疗8周后临床治疗效果及外周血CD4+、CD25+Treg细胞、淋巴细胞亚群表达水平。结果观察组患儿的治疗总有效率为91.67%,明显高于对照组的75.00%,差异有统计学意义(P<0.05);治疗后,观察组患儿的发热消失时间、皮疹、淋巴结肿大及黏膜充血消退时间分别为(2.05±1.44)d、(3.02±0.88)d、(6.01±3.20)d、(4.13±2.45)d,明显短于对照组的(3.13±1.33)d、(4.01±0.26)d、(8.24±3.58)d、(6.03±2.58)d,差异均有统计学意义(P<0.05);治疗后,两组患儿的外周血CD4+、CD25+Treg细胞表达水平均明显升高,且观察组外周血CD4+、CD25+Treg细胞表达水平分别为(43.46±2.19)%、(40.35±2.98)%,明显高于对照组的(36.24±2.04)%、(30.30±3.25)%,差异均有统计学意义(P<0.05);治疗后,两组患儿的CD3+、CD8+、自然杀伤(NK)细胞表达水平均明显升高,且观察组的CD3+、CD8+、NK细胞表达水平分别为(79.94±11.71)%、(25.12±6.03)%、(14.68±0.87)%,明显高于对照组的(70.87±10.03)%、(22.36±5.15)%、(10.07±0.58)%,差异均有统计学意义(P<0.05);治疗后,两组患儿的CD4+、CD4+/CD8+细胞表达水平均明显降低,且观察组CD4+、CD4+/CD8+细胞表达水平分别为(30.82±10.02)%、(1.02±0.11),明显低于对照组的(35.64±10.03)%、(2.67±0.42),差异均有统计学意义(P<0.05);观察组患儿治疗期间的不良反应发生率为10.42%,与对照组的6.25%比较差异无统计学意义(P>0.05)。结论丙种球蛋白联合阿司匹林治疗川崎病患儿临床疗效显著,其可有效缩短临�Objective To study the effect of gamma globulin combined with aspirin on peripheral blood Treg cells and lymphocytes in children with Kawasaki disease, and to provide guidance for clinical research. Methods A total of 96 children with Kawasaki disease admitted in the Second Hospital of Yulin City from January 2017 to February2020 were selected for study. They were divided into observation group and control group according to random number table method, with 48 patients in each group. The control group was treated with gamma globulin alone, and the observation group was treated with aspirin on the basis of the control group. Both groups were treated for 2 months. The disappearance time of clinical symptoms, clinical treatment effect after 8 weeks of treatment, the expression levels of CD4+, CD25+Treg cells, and lymphocyte subsets in peripheral blood of the two groups were observed and compared.Results After treatment, the total effective rate of the observation group was 91.67%, which was significantly higher than 75.00% of the control group(P<0.05). After treatment, the time of fever disappearance, rash, lymphadenopathy, and mucosal hyperemia disappeared in the observation group were(2.05 ± 1.44) d,(3.02 ± 0.88) d,(6.01 ± 3.20) d,(4.13 ±2.45) d, respectively, which were significantly shorter than(3.13±1.33) d,(4.01±0.26) d,(8.24±3.58) d,(6.03±2.58) d of the control group(P<0.05). After treatment, the expression levels of CD4+and CD25+Treg cells in the peripheral blood of the two groups of patients were increased significantly, while the expression levels of peripheral blood CD4+and CD25+Treg cells in the observation group were(43.46±2.19)% and(40.35±2.98)%, which were significantly higher than(36.24±2.04)% and(30.30±3.25)% of the control group(P<0.05). After treatment, the expression levels of CD3+, CD8+,and natural killer(NK) cells in the two groups were significantly increased, and the expression levels of CD3+, CD8+,and NK cells in the observation group were(79.94±11.71)%,(25.12±6.03)%,(14.68±0.

关 键 词：川崎病 阿司匹林 丙种球蛋白 疗效 免疫功能 淋巴细胞亚群 调节T细胞 

分 类 号：R729[医药卫生—儿科]