新生儿血清TBiL水平与凝血功能异常及继发性血小板增多症的相关性  

Correlation between neonatal serum TBiL level with abnormal coagulation function and secondary thrombocytosis

作　　者：刘增芳 曹珍珍[1] 贺兆平 LIU Zeng-fang;CAO Zhen-zhen;HE Zhao-ping(Department of Paediatrics,the Second Hospital of Yulin City,Yulin 719000,Shaanxi,CHINA)

机构地区：[1]榆林市第二医院儿科,陕西榆林719000

出　　处：《海南医学》2020年第24期3174-3177,共4页Hainan Medical Journal

摘　　要：目的探讨新生儿血清总胆红素(TBiL)水平与凝血功能异常及继发性血小板增多症的相关性,为患儿的临床诊疗提供相关指导。方法选择2018年3月至2020年3月于榆林市第二医院出生的134例高胆红素血症患儿为研究组,根据其血清TBiL水平将所有患儿分为研究A组(<257μmol/L,61例)和研究B组(>257μmol/L,73例),并选取同期134例血清TBiL正常的新生儿为对照组。检测并比较三组新生儿血小板计数(PLT)、凝血功能相关指标[包括活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)以及纤维蛋白原(FIB)]及继发性血小板增多症发生情况,并采用Pearson相关性分析法分析新生儿血清TBiL水平与凝血功能异常及继发性血小板增多症的相关性。结果研究组患儿的PLT、APTT、PT及TT分别为(429.54±76.75)×10^9个/L、(50.45±9.08)s、(21.51±5.09)s、(19.58±4.11)s,明显高于对照组的(280.78±65.14)×10^9个/L、(28.15±5.03)s、(13.05±3.57)s、(16.27±3.68)s,FIB水平为(1.52±0.42)g/L,明显低于对照组的(2.61±0.85)g/L,差异均有统计学意义(P<0.05);研究组患儿继发性血小板增多症发生率为21.64%,明显高于对照组的5.22%,差异有统计学意义(P<0.05);研究B组患儿PLT、APTT、PT及TT分别为(431.72±77.65)×10^9个/L、(51.22±9.34)s、(25.61±5.23)s、(22.73±5.15)s,明显高于研究A组的(416.52±70.12)×10^9个/L、(39.44±10.07)s、(16.39±4.12)s、(17.88±4.34)s,FIB水平为(1.60±0.45)g/L,明显低于研究A组的(2.35±0.72)g/L,差异均有统计学意义(P<0.05);研究A组和研究B组患儿继发性血小板增多症发生率分别为17.16%、22.39%,差异无统计学意义(P>0.05);Pearson相关性分析结果显示,新生儿血清TBiL水平与凝血功能异常及继发性血小板增多症呈正相关(r=0.673、0.122,P<0.05)。结论新生儿血清TBiL水平与凝血功能异常及继发性血小板增多症呈正相关,高胆红素血症患儿更容易引发凝血功能异常和继发性血�Objective To investigate the correlation between neonatal serum total bilirubin(TBiL)level and abnormal blood coagulation function and secondary thrombocythemia,and to provide relevant guidance for clinical diagnosis and treatment of children.Methods A total of 134 children with hyperbilirubinemia born in the Second Hospital of Yulin City from March 2018 to March 2020 were selected as the study group.According to their serum TBiL levels,all the children were divided into study group A(<257μmol/L,61 cases)and study group B(>257μmol/L,73 cases),and 134 neonates with normal serum TBiL were selected as the control group during the same period.The platelet count(PLT),blood coagulation function related indexes(includes activated clotting enzyme live time[APTT],prothrombin time[PT],thrombin time[TT],and fibrinogen[FIB]),and secondary thrombocytosis disease occurrence in the three groups were detected and compared.Pearson correlation was used to analyze the correlation between neonatal serum TBiL level and abnormal coagulation function and secondary thrombocytosis.Results The levels of PLT,APTT,PT,and TT in the study group were(429.54±76.75)×10^9/L,(50.45±9.08)s,(21.51±5.09)s,(19.58±4.11)s,which were significantly higher than(280.78±65.14)×10^9/L,(28.15±5.03)s,(13.05±3.57)s,(16.27±3.68)s in the control group,and the level of FIB was(1.52±0.42)g/L,which was significantly lower than(2.61±0.85)g/L of the control group(P<0.05).The incidence of secondary thrombocytopenia in the study group was 21.64%,which was significantly higher than 5.22%in the control group(P<0.05).The levels of PLT,APTT,PT,and TT in the study group B were(431.72±77.65)×10^9/L,(51.22±9.34)s,(25.61±5.23)s,(22.73±5.15)s,which were significantly higher than(416.52±70.12)×10^9/L,(39.44±10.07)s,(16.39±4.12)s,(17.88±4.34)s in the study group A,and the level of FIB was(1.60±0.45)g/L,which was significantly lower than(2.35±0.72)g/L of the study group A(P<0.05).There were significantly difference in the incidence of secondary thrombocytos

关 键 词：新生儿 高胆红素血症 总胆红素 凝血功能 继发性血小板增多症 相关性 

分 类 号：R722[医药卫生—儿科]