基于数据挖掘的中药治疗急性肾盂肾炎用药规律分析  

Study on the Law of Chinese Medicine in the Treatment of Acute Pyelonephritis Based on Data Mining

作　　者：谭晓宁 叶可平 于大君[1] TAN Xiao-ning;YE Ke-ping;YU Da-jun(Xiyuan Hospital,China Academy of Chinese Medicine Science,Beijing 100091,China)

机构地区：[1]中国中医科学院西苑医院,北京100091

出　　处：《中医药导报》2020年第16期163-166,181,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家科技支撑计划(2012BAI02B-01)。

摘　　要：目的:分析中药治疗急性肾盂肾炎的用药规律,为临床治疗本病提供参考。方法:计算机检索中国知网(CNKI)、维普数据库(VIP)、万方数据库及中国生物医学文献数据库(CBM)建库至2020年4月发表的中药治疗急性肾盂肾炎的相关文献,采用古今医案平台(V2.2.2)对所纳入处方的中药组成、中药性味归经及功效进行频数分析,并进行关联规则分析、聚类分析。结果:纳入处方91首,涉及药物146味,药性以寒性、微寒及平性为主;其中甘、苦、辛、淡味的药物使用频数最高;主归肺、肝、胃、心、膀胱五经;功效以利尿通淋、清热解毒、凉血解毒、清热燥湿等为主。处方中常用药对有滑石-甘草、萹蓄-瞿麦、栀子-大黄-车前子、黄芩-柴胡、白花蛇舌草-车前草-白茅根等。结论:中药治疗急性肾盂肾炎以清利下焦湿热,恢复肾与膀胱气化为主,用药多从利尿通淋、清热利湿着手,尤其重视使邪气从小便而解。从药物四气五味分析中得出,在清热利湿治疗本病时,要注意苦寒耗气伤阴之弊,多选用甘寒之品。Objective: To analyze the law of Chinese Medicine in the treatment of acute pyelonephritis and provide reference for the clinical treatment. Methods: Chinese knowledge resources database(CNKI), Chinese science and technology journal database(VIP), Chinese academic journal database(WanFang database) and Chinese biomedical literature database(CBM) were searched by computer from database construction to April, 2020. The cloud platform of ancient and modern medical cases(V2.2.2) were used to analyze the frequency of Chinese Medicine composition, properties and flavors, meridian distribution and efficacy, and association rules analysis and cluster analysis were carried out. Results: Totally 91 prescriptions were included, and 146 drugs were involved. Among them, the main properties are cold, mild cold and mild;The top frequency drug were sweet,bitter, pungent, light drug;The main meridian distribution were lung, liver, stomach, heart and bladder meridians;The main efficacy were diuretic tongdrench, heat-clearing detoxification, cold-blood detoxification and heatclearing dry wet, etc. The key prescriptions are Huanshi(Talc)-Gancao(Liquorice), Bianxu(Polygonum aviculare)-Qumai(Dianthus Superbus), Zhizi(Gardenia)-Dahuang(rhubarb)-Cheqianzi(plantain seed), Huangqin(Scutellariae)-Chaihu(Radix bupleuri) and Baihuasheshecao(Hedyotis diffusa)-Cheqiancao(Plantain)-Baimaogen(Cogongrass rhizome), etc. Conclusion: The treatment of acute pyelonephritis with Chinese Medicine is mainly focused on clearing the heat and dampness of the Xiajiao and recovering the Qi transformation of kidney and bladder. The drugs are used according to diuresis, clearing away heat and dampness, especially for eliminating evil Qi from urination. According to the analysis of the four properties and five flavors of the drug, in the treatment of the disease by clearing the heat and dampness, we should pay attention to the disadvantages of consumption of Qi and injury of Yin by bitter cold drugs, with more choice of sweet cold products.

关 键 词：急性肾盂肾炎 中药 用药规律 数据挖掘 

分 类 号：R256.52[医药卫生—中医内科学]