重庆地区儿童支气管哮喘遗传及环境影响因素调查研究  

An investigation study on genetic and environmental influencing factors on children asthma in Chongqing area

作　　者：蒋静[1] 李雪梅[1] 谢伍刚 王成秀[3] 曾书旬 Jiang Jing;Li Xuemei;Xie Wugang;Wang Chengxiu;Zeng Shuxun(Department of Pediatrics Outpatient,Chongqing Health Center for Women and Children;Department of Pediatrics,Chongqing Hechuan District Maternal and Child Health Hospital;Department of Pediatrics,The Fifth People’s Hospital of Chongqing)

机构地区：[1]重庆市妇幼保健院儿科,重庆401147 [2]重庆市合川区妇幼保健院儿科,重庆401520 [3]重庆市第五人民医院儿科,重庆400062

出　　处：《重庆医科大学学报》2020年第12期1739-1742,共4页Journal of Chongqing Medical University

基　　金：重庆市科委资助项目(编号:cstc2016jcyjA0324)。

摘　　要：目的:探讨重庆地区儿童支气管哮喘发病的遗传及环境影响因素。方法:选取2016年5月至2019年5月就诊于重庆市3个不同区县医疗机构的支气管哮喘患儿310例纳入病例组,并选取同期、同性别、同年龄段非哮喘儿童310例纳入对照组。调查2组母孕期基本情况、婴幼儿期喂养和疾病情况、社会家庭因素等哮喘发病相关因子,使用卡方检验筛选出P<0.05的单因素,以其作为logistic回归模型的自变量作多因素分析,得出影响儿童支气管哮喘的高危因素。结果:影响儿童支气管哮喘的单因素共16项,logistic多因素回归分析后儿童支气管哮喘发病的独立影响因素共11项,其中血亲过敏性疾病、母孕期烟雾接触、宠物接触、城市居住、父亲高压力等是哮喘的独立高危因素,而半岁内母乳喂养、母乳不足时添加水解蛋白配方奶喂养、父母学历本科及以上是哮喘的保护因素。结论:积极识别、合理规避或利用儿童哮喘的高危因素和保护因素,对预防和控制儿童哮喘具有重要意义。Objective:To investigate the genetic and environmental factors influencing bronchial asthma in children in Chongqing area.Methods:A total of 310 children with bronchial asthma who visited medical institutions in three different districts and counties of Chongqing from May 2016 to May 2019 were selected as the case group,and 310 non-asthmatic children with same gender and age group during that period were selected as the control group.Factors related to the incidence of asthma between two groups,such as the basic situation throughout pregnancy,infant feeding and disease and social and family factors were investigated.The chi-square test was used to screen the single factor with P<0.05,which was used as the independent variable of the logistic regression model for multi-factor analysis,obtaining risk factors influencing children’s bronchial asthma.Results:There were 16 single factors influencing children’s asthma.After logistic multiple factor regression analysis,11 were independent factors influencing children’s asthma among which the independent high risk factors of asthma were the allergic diseases of consanguinity,smoke inhalation during pregnancy,pet exposure,urban living and fathers’high pressure,while breastfeeding within 6 months of age,feeding with hydrolyzed protein formula when insufficient breast milk,parents with bachelor or above degree were the protection factor.Conclusion:It is important to identify,avoid or utilize the risk factors and protective factors of childhood asthma.

关 键 词：儿童支气管哮喘 影响因素 多因素分析 

分 类 号：R725.6[医药卫生—儿科]