胆红素、C反应蛋白水平与急性心肌梗死患者PCI术后长期预后的关系分析  

Correlation between bilirubin,C-reactive protein and long-term prognosis of patients with acute myocardial infarction after PCI

作　　者：邓淑玲[1] 吕明义[1] 龙晓凤[1] DENG Shu-ling;LYU Ming-yi;LONG Xiao-feng(MICU Department,Affiliated Zhongshan Hospital of Dalian University,Dalian 116001,China)

机构地区：[1]辽宁省大连市大连大学附属中山医院MICU科,116001

出　　处：《中国现代药物应用》2021年第1期1-3,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨血清胆红素和C反应蛋白水平与急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后长期预后的关系。方法选取80例AMI患者为研究组,选取同期体检中心的80例同龄健康体检者为对照组。根据研究组随访结果,若患者在PCI手术后出现不良反应均纳入为事件组(23例),其余患者作为非事件组(57例)。分别比较对照组与研究组、事件组与非事件组患者总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)和血清C反应蛋白水平。结果研究组患者血清TBIL(14.13±1.54)μmol/L、DBIL(2.96±1.38)μmol/L和IBIL(10.67±1.61)μmol/L均低于对照组的(17.03±1.87)、(4.08±0.27)、(13.89±1.92)μmol/L,血清C反应蛋白(13.21±2.55)mg/L高于对照组的(1.99±1.32)mg/L,差异均具有统计学意义(P<0.05)。事件组患者血清TBIL(13.58±1.57)μmol/L、DBIL(2.01±1.98)μmol/L和IBIL(9.36±2.65)μmol/L均低于非事件组的(14.61±2.15)、(2.99±1.84)、(10.81±2.57)μmol/L,血清C反应蛋白(14.42±2.97)mg/L高于非事件组的(11.33±2.83)mg/L,差异均具有统计学意义(P<0.05)。结论血清胆红素浓度降低和C反应蛋白浓度升高时,可增加AMI的患病率。AMI患者在进行PCI手术后不良事件发生与患者血清胆红素和血清C反应蛋白水平相关,血清胆红素浓度的降低和C反应蛋白浓度的升高可以增加PCI术后的AMI患者不良事件的发生率。Objective To discuss the correlation between bilirubin,C-reactive protein and long-term prognosis of patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods There were 80 AMI patients selected as the research group,and another 80 healthy subjects of the same age from the physical examination center at the same time as the control group.According to the follow-up results of the research group,patients with adverse reactions after PCI were included in the event group(23 cases),and the remaining patients were treated as the non-event group(57 cases).The total bilirubin(TBIL),direct bilirubin(DBIL),indirect bilirubin(IBIL)and serum C-reactive protein levels were compared between the control group and the research group,event group and non-event group.Results The serum TBIL(14.13±1.54)μmol/L,DBIL(2.96±1.38)μmol/L and IBIL(10.67±1.61)μmol/L of the research group were lower than(17.03±1.87),(4.08±0.27)and(13.89±1.92)μmol/L of the control group,and serum C-reactive protein(13.21±2.55)mg/L was higher than(1.99±1.32)mg/L of the control group,and the difference was statistically significant(P<0.05).The serum TBIL(13.58±1.57)μmol/L,DBIL(2.01±1.98)μmol/L and IBIL(9.36±2.65)μmol/L of the event group were lower than(14.61±2.15),(2.99±1.84)and(10.81±2.57)μmol/L of non-event group,and serum C-reactive protein(14.42±2.97)mg/L was higher than(11.33±2.83)mg/L of non-event group,and the difference was statistically significant(P<0.05).Conclusion Decreased serum bilirubin concentration and increased C-reactive protein concentration can increase the prevalence of AMI.The incidence of adverse events in patients with AMI after PCI is correlated to the level of serum bilirubin and serum C-reactive protein.The decrease of serum bilirubin concentration and the increase of C-reactive protein concentration can increase the incidence of adverse events in AMI patients after PCI.

关 键 词：胆红素 C反应蛋白 急性心肌梗死 预后 

分 类 号：R542.22[医药卫生—心血管疾病]