唑吡坦与阿普唑仑治疗失眠症有效性与安全性的Meta分析  

Efficacy and safety of zolpidem and alprazolam for insomnia:a meta-analysis

作　　者：张巍献 路淑淑 何云鹏[1] 刘增训[1,2] 周莉 ZHANG Weixian;LU Shushu;HE Yunpeng(Shandong Mental Health Center,Jinan 250014,China)

机构地区：[1]山东省精神卫生中心,山东济南250014 [2]山东大学临床医学院

出　　处：《精神医学杂志》2020年第5期363-366,共4页Journal of Psychiatry

基　　金：山东省医药卫生科技发展计划项目(编号:2017WSB06)。

摘　　要：目的系统评价唑吡坦与阿普唑仑治疗失眠患者的有效性及安全性。方法计算机检索数据库,纳入唑吡坦、阿普唑仑治疗失眠症的随机对照试验,进行Meta分析。结果纳入9项研究,共计760例患者,两组研究的匹兹堡睡眠质量指数量表(PSQI)减分值比较差异具有统计学意义[P=0.007,OR(95%CI)=-2.32(-4.00^-0.64)];两组不良反应发生率比较差异具有统计学意义[P=0.002,OR(95%CI)=0.40(0.23~0.71)]。两组PSQI评分总有效率和睡眠障碍量表(SDRS)有效率比较,差异均无统计学意义(P>0.05)。结论与阿普唑仑相比,唑吡坦治疗失眠症的有效性和安全性更优。Objective To evaluate the efficacy and safety of zolpidem and alprazolam in the treatment of insomnia.Methods Randomized controlled trials(RCTs)assessing zolpidem and alprazolam in the treatment of insomnia were retrieved from database by computer,and included in the meta-analysis.Results A total of 9 RCTs involving 760 patients were identified.There were statistically significant differences in Pittsburgh Sleep Quality Index(PSQI)subtraction scores[P=0.007,OR(95%CI)=-2.32(-4.00^-0.64)]and incidence rates of adverse events[P=0.002,OR(95%CI)=0.40(0.23~0.71)]between two groups.There were no statistically significant differences in total effective rates of PSQI and Sleep Dysfunction Rating Scale(SDRS)respectively between two groups(P>0.05).Conclusion Compared with alprazolam,zolpidem has better efficacy and more safety in treating insomnia.

关 键 词：唑吡坦 阿普唑仑 失眠症 META分析 

分 类 号：R969.4[医药卫生—药理学]