Ⅱ型糖尿病动物模型构建的研究进展  

Research progress in the construction of type Ⅱ diabetes animal models

作　　者：唐艺丹 王鲜忠[1] 张姣姣[1] TANG Yidan;WANG Xianzhong;ZHANG Jiaojiao(College of Veterinary Medicine,Southwest University,Chongqing 400715,China)

机构地区：[1]西南大学动物医学院,重庆400715

出　　处：《中国实验动物学报》2020年第6期870-876,共7页Acta Laboratorium Animalis Scientia Sinica

基　　金：重庆市自然科学基金面上项目(cstc2019jcyj-msxmX0056);重庆市高等教育教学改革研究项目(203259);西南大学科技论文写作课程思政项目。

摘　　要：糖尿病是以高血糖为特征的多因素引发的代谢性疾病,对人类的健康造成了严重威胁。构建相应的糖尿病动物模型对研究其发病机制、预防、诊断及新治疗药物的筛选具有十分重要的意义。本文在概述自发性和诱导性Ⅱ型糖尿病动物模型构建的基础上,重点阐述了利用基因工程技术构建Ⅱ型糖尿病动物模型的方法,并探讨了各种构建方法的优缺点,旨在为揭示糖尿病的发病机制及治疗提供合适的动物模型。Diabetes mellitus is a metabolic disease characterized by hyperglycemia and caused by many factors.Diabetes poses a serious threat to human health.It is of great significance to construct a corresponding animal model of diabetes to study its pathogenesis,prevention,and diagnosis and to screen new drugs.On the basis of summarizing the construction of animal models of spontaneous and induced type Ⅱ diabetes,this paper focused on the construction of animal models of type Ⅱ diabetes using genetic engineering technology and discussed the advantages and disadvantages of various construction method to provide appropriate animal models for unraveling the pathogenesis and treatment of diabetes.

关 键 词：Ⅱ型糖尿病 动物模型 STZ 基因编辑 

分 类 号：Q95-33[生物学—动物学]