A concise total synthesis of natural flavonols  

作　　者：Gaigai Liu Shunqiang Gong Zhan Li Xingyi Du Xiaolou Miao Xuhong Ren 

机构地区：[1]School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China [2]Key Laboratory of New Animal Drug Project of Gansu Province,Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences,Lanzhou 730050,China

出　　处：《Journal of Polyphenols》2020年第1期35-42,共8页多酚杂志（英文）

基　　金：Science and Technology Project of Gansu Province(grant No.18YF1NA128);the Natural Science Foundation of Liaoning Province(grant No.201602712).

摘　　要：In this study,we designed a convenient method,to total synthesis of fl avonols especially for C-5 substituted ones and derivatives on a large scale.Beginning from the inexpensively available 2,4,6-trihydroxyacetophenone through Aldol condensation reaction,I2/DMSO cyclization reaction,Oxone“one pot”oxidation,kaempferol(1)and derivative(2)was obtained in an overall yield of 35%.The structures of the target compound and key intermediates were verifi ed by MS,IR,1H-NMR and 13C-NMR techniques,and the structure of 5a was further confi rmed by X-ray diff raction analysis.

关 键 词：FLAVONOL I2/DMSO cyclization oxidation 

分 类 号：O62[理学—有机化学]