静止性脑梗死患者认知损害的影响因素研究  

Clinical related factors of cognitive impairment in patients with static cerebral infarction

作　　者：李晨 胡义芳 薄茂林 刘红 张琨 杨惠芳 李经纶 LI Chen;HU Yifang;BO Maolin;LIU Hong;ZHANG Kun;YANG Huifang;LI Jinglun(Henan Geriatric Hospital,Zhengzhou 450003,China;Henan University of Economics and Law,Zhengzhou 450031,China;The 988th Hospital of PLA,Zhengzhou 450052,China)

机构地区：[1]河南省老年医院,河南郑州450003 [2]河南财经政法大学,河南郑州450031 [3]解放军第988医院,河南郑州450052

出　　处：《中国实用神经疾病杂志》2020年第23期2068-2073,共6页Chinese Journal of Practical Nervous Diseases

基　　金：解放军联勤保障部队面上项目(编号:CJN16J004)。

摘　　要：目的探讨静止性脑梗死(SCI)的认知损害程度及其影响因素。方法应用韦氏智力量表,对经CT或MRI证实的143例SCI患者进行神经心理学测评,并与临床性脑梗死(CCI)组176例及正常对照组129例进行比较。对SCI组内智能障碍者与非智能障碍者的梗死病灶情况(数量、侧别、部位)、人口学情况(性别、年龄、文化程度、婚姻状况、慢性病史)进行统计分析。结果SCI组23例存在智能障碍,其构成比与CCI组45例比较差异无统计学意义;智能障碍者在病灶数量(多灶)、部位(颞叶/侧脑室旁/丘脑)、文化程度(小学以下)、既往基础病史(糖尿病/甲状腺功能减退),与非智能障碍者有显著性差异(P<0.01)。结论静止性脑梗死,其认知障碍的程度与症状性脑梗死等同。多发性脑梗死、颞叶梗死、侧脑室旁梗死、丘脑梗死、小学以下文化程度、糖尿病史、甲状腺功能减退史是SCI认知障碍的危险因素。Objective To investigate the cognitive impairment and its influencing factors in static cerebral infarction(SCI).Methods Using Wechsler Intelligence Scale,143 patients with SCI confirmed by CT or MRI were evaluated by neuropsychological evaluation,and compared with 176 cases of clinical cerebral infarction(CCI)group and 129 cases of normal control group.In the SCI group,the infarct lesions(number,side,location),demography(gender,age,education level,marital status,chronic medical history)of patients with and without mental impairment were statistically analyzed.Results There was no significant difference in the constituent ratio between SCI group and SCI group.There were significant differences in the number of lesions(multifocal),location(temporal lobe/paraventricular/thalamus),educational level(below primary school)and previous basic medical history(diabetes/hypothyroidism)between the patients with mental retardation and those without mental retardation(P<0.01).Conclusion Static cerebral infarction has the same cognitive impairment as symptomatic cerebral infarction.Multiple cerebral infarction,temporal lobe infarction,paraventricular infarction,thalamic infarction,educational level below primary school,history of diabetes mellitus and hypothyroidism were risk factors of cognitive impairment in SCI.

关 键 词：静止性脑梗死 无症状性脑梗死 认知障碍 智能障碍 

分 类 号：R745.11[医药卫生—神经病学与精神病学]