重视供肝机械灌注研究,推动肝移植高质量发展  

Attaching importance to mechanical perfusion of donor liver and promoting high-quality development of liver transplantation

作　　者：欧阳青 谭晓宇 霍枫 Ouyang Qing;Tan Xiaoyu;Huo Feng(Department of Hepatobiliary Surgery,Liver Transplantation Center,General Hospital of Southern Theater of Chinese People's Liberation Army,Guangzhou 510010,China)

机构地区：[1]中国人民解放军南部战区总医院肝胆外科暨肝移植中心,广州510010

出　　处：《器官移植》2021年第1期1-7,共7页Organ Transplantation

基　　金：国家自然科学基金青年项目(81800556);军队实验动物专项科研项目[SYDW(2017)12]。

摘　　要：随着器官捐献数量不断增加和扩大标准供者(ECD)供肝定义不断拓展,供肝质量必然成为影响肝移植高质量发展的突出问题,也是相关领域的研究重点。最大限度解决器官短缺和推动器官移植高质量发展是我国器官捐献与移植事业发展的方向。近年来,利用机械灌注(MP)对供肝进行灌注、保存、评估及修复,已成为当前国际上提高肝移植质量的研究热点。本文针对国内外ECD供肝的不同应用情况,结合国际上MP研究进展和本中心有关研究经验,探讨整合器官保护技术建设器官重症监护室(ICU)的可行性,拟在推动我国器官移植高质量发展同时,进一步丰富器官捐献与移植“中国模式”的技术内涵。With the increasing quantity of organ donors and the continual expansion of the definition of extended criteria donor(ECD)livers,the quality of donor liver has become a prominent issue affecting the high-quality development of liver transplantation,which is also the study focus in related fields.Resolving the shortage of organs to the maximal extent and promoting the high-quality development of organ transplantation lead the development direction of organ donation and transplantation in China.In recent years,the application of mechanical perfusion(MP)for the perfusion,preservation,evaluation and repair of donor liver has become a hot topic to improve the quality of liver transplantation within the international community.In this article,according to different conditions of the application of ECD livers in liver transplantation at home and abroad in combination with the research progress on MP in the international community and relevant research experience of our center,the feasibility of establishing an organ intensive care unit(ICU)with integrated organ protection techniques was discussed,aiming to promote the high-quality development of organ transplantation in China and further expand the technical connotation of the"Chinese model"of organ donation and transplantation.

关 键 词：机械灌注 器官移植 肝移植 重症监护室(ICU) 扩大标准供者(ECD) 器官捐献 器官保护 体外膜肺氧合 

分 类 号：R617[医药卫生—外科学]