细胞凋亡、细胞焦亡、坏死性凋亡异同与交互  

The similarities,differences and crosstalks of apoptosis,pyroptosis and necroptosis

作　　者：汪蒙蒙[1] 韩岚[1] 刘竹青[1] 彭代银[1,2] WANG Mengmeng;HAN Lan;LIU Zhuqing;PENG Daiyin(Anhui University of Chinese Medicine,Anhui Province Key Laboratory of Chinese Medicinal Formula,Hefei 230012,China;Key Laboratory of Xin'an Medicine,Ministry of Education,Hefei 230012,China)

机构地区：[1]安徽中医药大学,中药复方安徽省重点实验室,合肥230012 [2]新安医学教育部重点实验室,合肥230012

出　　处：《生命的化学》2020年第11期1932-1940,共9页Chemistry of Life

基　　金：国家自然科学基金项目(81903953)。

摘　　要：随着对细胞死亡研究的不断深入,不同程序性细胞死亡之间的相似、差异和交互串联关系逐渐被发现。细胞凋亡、细胞焦亡、坏死性凋亡是常见的程序性死亡。它们之间在形态和分子机制方面存在一些相似和不同之处。本文就细胞凋亡、细胞焦亡和坏死性凋亡的异同和交互进行综述,以便清晰地认识这些程序性细胞死亡,为疾病靶点的药物研发提供理论依据。With the study of cell deaths,the similarities,differences,and crosstalks were discovered in different programmed cell deaths.Apoptosis,pyroptosis,and necroptosis are common programmed cell deaths.There are some similarities and differences in morphology and molecular mechanisms.In this paper,the similarities,differences,and crosstalks are reviewed in apoptosis,pyroptosis,and necroptosis,which can understand these programmed cell deaths clearly,and provide a theoretical basis for drug development of disease targets.

关 键 词：细胞凋亡 细胞焦亡 坏死性凋亡 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]