血尿安胶囊联合左氧氟沙星治疗慢性细菌性前列腺炎的疗效观察  

Therapeutic effect of Xueniaoan Capsule combined with levofloxacin on chronic bacterial prostatitis

作　　者：万军[1] 包奇昌[2] 傅斌[1] 黄勇[2] WAN Jun;BAO Qi-chang;FU Bin;HUANG Yong(Jiangxi College of Traditional Chinese Medicine,Fuzhou 344000,China;Affiliated Hospital of Jiangxi College of Traditional Chinese Medicine(Fuzhou First Hospital of Traditional Chinese Medicine),Fuzhou 344000,China)

机构地区：[1]江西中医药高等专科学校,江西抚州344000 [2]江西中医药高等专科学校附属医院(抚州市第一中医医院),江西抚州344000

出　　处：《中草药》2020年第23期6050-6053,共4页Chinese Traditional and Herbal Drugs

基　　金：第六届全国名老中医药专家学术经验继承工作项目。

摘　　要：目的探讨血尿安胶囊联合左氧氟沙星治疗慢性细菌性前列腺炎的临床疗效。方法 126例慢性细菌性前列腺炎患者随机分为对照组(60例)和治疗组(66例)。对照组为左氧氟沙星组,给予盐酸左氧氟沙星片(0.6 g/d)治疗;治疗组为联合用药组,给予血尿安胶囊(4.2 g/d)联合盐酸左氧氟沙星片(0.6 g/d)治疗。两组均连续治疗8周。观察两组的临床疗效,比较NIH-CPSI评分、前列腺液细菌培养转阴率、血清学指标及不良反应。结果治疗后,对照组和治疗组的总有效率分别是66.67%、89.39%,两组比较差异具有统计学意义(P<0.05)。治疗后,对照组和治疗组慢性前列腺炎症状指数(NIH-CPSI)的疼痛症状评分(5.45±1.12)、排尿症状评分(3.31±0.70)、生活质量评分(3.08±0.55)均低于本组治疗前(P<0.05),且治疗组均低于对照组,差异具有统计学意义(P<0.05)。治疗后,对照组和治疗组的前列腺液细菌培养转阴率分别是71.67%、92.42%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、超敏C反应蛋白(hs-CRP)水平均较治疗前显著降低(P<0.05),而治疗组炎症因子水平均低于对照组(P<0.05)。结论血尿安胶囊联合左氧氟沙星治疗慢性细菌性前列腺炎疗效确切,可以有效缓解患者的临床症状、提高前列腺液细菌培养转阴率,并降低患者的血清炎症因子水平,具有一定的临床推广应用价值。Objective To investigate the clinical efficacy of Xueniaoan Capsule combined with levofloxacin in the treatment of chronic bacterial prostatitis. Methods A total of 126 patients with chronic bacterial prostatitis were randomly divided into control group(n = 60) and observation group(n = 66). The control group was treated with levofloxacin hydrochloride tablets(0.6 g/d, po) and the observation group was treated with Xueniaoan Capsule(4.2 g/d, po) combined with levofloxacin hydrochloride tablets(0.6 g/d, po). Both groups were continuously treated for eight weeks. The clinical efficacy of the two groups was evaluated through the NIH-CPSI score, prostatic fluid bacterial culture negative conversion rate, and serological parameters. Results After treatment, the clinical efficacy in the control and treatment groups were 66.67% and 89.39%, respectively, and there were statistical differences between two groups(P < 0.05);Statistical analysis showed that the pain symptom score(5.45 ± 1.12), urination symptom score(3.31 ± 0.70) and quality of life score(3.08 ± 0.55) of NIH-CPSI scale in the observation group were significantly lower than those of the control group(P < 0.05);The negative conversion rate of prostatic fluid bacterial culture was 71.67% in the control group and 92.42% in the observation group, and the difference between the two groups had statistical significance(P < 0.05);The serum levels of interleukin-6(IL-6), interleukin-8(IL-8), and high-sensitivity C-reactive protein(hs-CRP) in the two groups were significantly lower than those before treatment(P < 0.05), while the levels of inflammatory factors in the observation group were significantly lower than those in the control group(P < 0.05). Conclusion Xueniaoan Capsule combined with levofloxacin is effective in the treatment of chronic bacterial prostatitis, and can effectively relieve the clinical symptoms, improve the rate of prostatic fluid bacterial clearance, and reduce the level of serum inflammatory factors, which has a certain clinical application

关 键 词：慢性细菌性前列腺炎 血尿安胶囊 盐酸左氧氟沙星片 NIH-CPSI评分 前列腺液细菌转阴率 

分 类 号：R28[医药卫生—中药学]