基于信号通路的中药有效成分治疗骨质疏松机制研究进展  

Research progress on mechanism of active components of Chinese materia medica in treatment of osteoporosis based on signaling pathway

作　　者：赵金龙[1,2] 曾令烽 梁桂洪 黄和涛[1,2] 杨伟毅 罗明辉[2,3] 潘建科 李嘉晖 刘军[2,3] ZHAO Jin-long;ZENG Ling-feng;LIANG Gui-hong;HUANG He-tao;YANG Wei-yi;LUO Ming-hui;PAN Jian-ke;LI Jia-hui;LIU Jun(The Second School of Clinical Medical Sciences,Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Research Team on Bone and Joint Degeneration and Injury,Guangdong Academy of Traditional Chinese Medicine,Guangzhou 510120,China;The Second Affiliated Hospital(Guangdong Province Hospital of Traditional Chinese Medicine),Guangzhou University of Chinese Medicine,Guangzhou 510120,China)

机构地区：[1]广州中医药大学第二临床医学院,广东广州510405 [2]广东省中医药科学院,骨与关节退变及损伤研究团队,广东广州510120 [3]广州中医药大学第二附属医院(广东省中医院),广东广州510120

出　　处：《中草药》2020年第23期6084-6094,共11页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82004383);国家自然科学基金资助项目(81974574);国家自然科学基金资助项目(81473698);广东省财政厅资助项目([2014]157,[2018]8号);广东省中医院中医药科学技术研究专项(YN2019ML08,YK2013B2N19,YN2015MS15);中国博士后科学基金资助项目(2018M633036);广东省医学科学技术研究基金项目(B2019091,A2017215);广东省中医药管理局项目(20201129,20164020,20181119);教育部高等学校博士点科研基金项目(20124425110004);广东省科技计划项目(2020A1414050050);广东省普通高校重点科研平台和科研项目(2018KQNCX041)。

摘　　要：骨质疏松是一种全身骨骼疾病,对患者及社会均产生巨大的医疗负担。药物治疗是抗骨质疏松的主要干预措施,但客观存在的不良反应降低了患者的服用依从性从而影响用药效果。中医药防治骨质疏松具有较好的疗效以及安全性,但其作用机制需深入研究。通路调控骨质疏松的进展,是进行骨质疏松病理机制和药理学研究的主要靶点之一。近几年,针对中药有效成分对骨质疏松信号通路的调控机制作了大量研究。综述近年来有关中药有效成分干预生物学信号通路的相关研究成果,为抗骨质疏松症的新药开发、基础研究以及临床应用提供思路。Osteoporosis is a systemic skeletal disease that causes a huge medical burden on patients and society. Drug treatment is the main intervention for anti-osteoporosis, but objectively existing adverse reactions reduce the patient’s compliance and affect the effect of medication. Traditional Chinese medicine has good curative effect and safety in the prevention and treatment of osteoporosis, but its mechanism of action needs to be further studied. The pathway regulates the progress of osteoporosis and is one of the main targets for osteoporosis pathological mechanism and pharmacological research. In recent years, an increasing number of studies have been made on the regulatory mechanism of osteoporosis signaling pathways by active ingredients of Chinese materia medica. Recent research results on the active components of Chinese materia medica interfering with biological signaling pathways was reviewed in this article, in order to provide ideas for new drug development, basic research, and clinical applications for osteoporosis.

关 键 词：中药 有效成分 骨质疏松 信号通路 作用机制 促进骨形成 抑制骨吸收 

分 类 号：R285[医药卫生—中药学]