节茎石仙桃醋酸乙酯部位的化学成分研究  

Chemical constituents from ethyl acetate extracts of Pholidota articulata

作　　者：朱秀英 周昱彤 晏和贵 付欢 郭洁 杨明惠 ZHU Xiu-ying;ZHOU Yu-tong;YAN He-gui;FU Huan;GUO Jie;YANG Ming-hui(School of Pharmaceutical Sciences and Chemistry,Dali University,Dali 671000,China)

机构地区：[1]大理大学药学与化学学院,云南大理671000

出　　处：《中草药》2020年第24期6151-6156,共6页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81160393);大理大学创新团队(ZKLX2019216)。

摘　　要：目的研究节茎石仙桃Pholidotaarticulata全草醋酸乙酯部位的化学成分。方法利用硅胶和SephadexLH-20凝胶柱色谱进行分离纯化,通过NMR光谱数据分析和与标准品对比分析鉴定化合物结构。结果从节茎石仙桃78%乙醇提取物中分离得到17个化合物,分别鉴定为2,7-二羟基-9,10-二氢-六氢菲[4,5-环]吡喃(1)、2,6-二羟基-7-甲氧基-9,10-二氢-五氢菲[4,5-环]吡喃(2)、2,7-二羟基-6-甲氧基-9,10-二氢-五氢菲[4,5-环]吡喃(3)、2,7-二羟基-4-甲氧基-9,10-二氢菲(4)、4,7-二羟基-2-甲氧基-9,10-二氢菲(5)、2,5-二羟基-4-甲氧基-9,10-二氢菲(6)、石斛酚(7)、山药素Ⅲ(8)、5,3′-二羟基-3-甲氧基联苄(9)、cirrhopetalidin(10)、β-谷甾醇(11)、豆甾醇(12)、glut-5-en-3-ol(13)、月桂酸(14)、4-(4′-羟基-苄基)苯酚(15)、3-甲氧基苯甲醛(16)、反式桂皮酸(17)。结论化合物3~17为首次从该植物中分离得到,其中,化合物9、10、13和16为首次从石仙桃属植物中分离得到。Objective To study the chemical constituents of ethyl acetate extract from the whole herb of Pholidota articulata. Methods Silica gel and Sephadex LH-20 gel column chromatographic techniques were used to separate and purify the chemical constituents. Their structures were elucidated based on NMR spectroscopic and reported data. Results A total of 17 compounds were isolated from 78% ethyl acetate extracts of P. articulata and identified as flavidin(1), flaccidin(2), imbricatin(3), coelonin(4), lusianthridin(5), hircinol(6), gigantol(7), batatasin Ⅲ(8), 5,3′-dihydroxy-3-methoxybibenzyl(9), cirrhopetalidin(10), β-sitosterol(11), stigmasterol(12), glut-5-en-3-ol(13), laurostearic acid(14), 4, 4′-dihydroxydiphenylmethane(15), 3-methoxy-benzaldehyde(16), and trans-cinnamic acid(17). Conclusion Compounds 3—17 are isolated from this plant for the first time. In addition, compounds 9, 10, 13, and 16 are found in the genus Pholidota for the first time.

关 键 词：节茎石仙桃 菲 联苄 cirrhopetalidin glut-5-en-3-ol 

分 类 号：R282.1[医药卫生—中药学]