中药抗乙肝病毒活性及作用机制的研究进展  

Research progress on anti-hepatitis B virus activity and mechanisms of traditional Chinese medicine

作　　者：伍磊 张志鹏 蔡文涛[1] 温海梅 陈勇[1] WU Lei;ZHANG Zhi-peng;CAI Wen-tao;WEN Hai-mei;CHEN Yong(Hubei Key Laboratory of Biotechnology of Chinese Traditional Medicine,State Key Laboratory of Biocatalysis and Enzyme Engineering,National&Local Joint Engineering Research Center of High-throughput Drug Screening Technology,School of Life Sciences,Hubei University,Wuhan 430062,China)

机构地区：[1]湖北大学生命科学学院药物高通量筛选技术国家地方联合工程研究中心,省部共建生物催化与酶工程国家重点实验室,中药生物技术湖北省重点实验室,湖北武汉430062

出　　处：《中草药》2020年第24期6367-6376,共10页Chinese Traditional and Herbal Drugs

基　　金：药物高通量筛选技术国家地方联合工程研究中心开放基金资助项目(M20181009);2019年度药学“荆楚卓越协同育人计划”大学生创新训练计划项目(M20191004);2017年度中药生物技术省重点实验室开放基金资助项目。

摘　　要：乙肝病毒是一种能导致机体产生急性或慢性乙型肝炎(乙肝)的嗜肝性DNA病毒。乙肝现已成为全球性公共卫生疾病,易恶化发展为肝硬化、肝衰竭,甚至肝癌,严重威胁着人类的健康。中药及其活性成分发挥着重要的抗乙肝病毒活性,对中药抗乙肝病毒活性及其作用机制进行综述,以期为今后抗乙肝病毒研究提供一定的参考。Hepatitis B virus(HBV) is a hepatotropic DNA virus that can cause acute or chronic hepatitis B. Hepatitis B has become a worldwide public health disease, likely to develop into cirrhosis, hepatic failure or even hepatoma, which seriously threatens the human’s health. Chinese materia medica and its active ingredients play an important anti-HBV activity. Research progress on anti-HBV activities and mechanisms of traditional Chinese medicine is summarized in this paper, in order to provide the reference for future research on anti-HBV.

关 键 词：中药 乙肝病毒 抗病毒 活性 作用机制 

分 类 号：R282.71[医药卫生—中药学]