白桦酯酸及其衍生物的生物活性及作用机制研究进展  

Research progress on biological activities and mechanism of betulinic acid and their derivatives

作　　者：李影[1] 徐林琳 张一彤 田红梅[3] 詹亚光[1,2] 尹静[1,2] LI Ying;XU Lin-lin;ZHANG Yi-tong;TIAN Hong-mei;ZHAN Ya-guang;YIN Jing(Key Laboratory of Saline-alkali Vegetation Ecology Restoration,Ministry of Education,Northeast Forestry University,Harbin 150040,China;College of Life Sciences,Northeast Forestry University,Harbin 150040,China;Forest Botanical Garden of Heilongjiang,Harbin 150040,China)

机构地区：[1]东北林业大学东北盐碱植被恢复与重建教育部重点实验室,黑龙江哈尔滨150040 [2]东北林业大学生命科学学院,黑龙江哈尔滨150040 [3]黑龙江省森林植物园,黑龙江哈尔滨150040

出　　处：《中草药》2020年第24期6377-6390,共14页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(31570589);东北林业大学本科创新项目(201910225082);中央高校基本科研业务资助项目(2572020DY22)。

摘　　要：白桦酯酸是一种天然存在的五环戊烷型三萜类物质,通常是从白桦Betula platyphylla树皮中分离出来,在其他植物中也有发现,以游离糖苷和糖基衍生物的形式存在于不同植物中。通过对其化学结构的修饰可以得到多种多样的衍生物,研究表明白桦酯酸及其衍生物在抗肿瘤、抗病毒、消炎止痛、抑制脑神经及血管损伤和对其他常见疾病的治疗作用等方面具有积极的作用。综述了白桦酯酸及其衍生物的种类、生物活性及作用机制,以期为今后对其进一步的研究与应用提供理论参考。Betulinic acid is a natural pentacyclic pentane triterpenoid, usually isolated from the bark of Betula platyphylla, or in the form of free glycosides and glycosyl derivatives in various plants. A variety of derivatives can be obtained by modifying its chemical structure. Betulinic acid and its derivatives have certain regulatory effects in anti-tumor, antiviral, anti-inflammatory, analgesic, inhibition of cerebral nerve and vascular injury, and treatment of other common diseases. The category, pharmacological activities and related mechanisms of betulinic acid and its derivatives are reviewed in this paper, in order to provide a theoretical reference for the future application.

关 键 词：白桦酯酸 白桦酯醇 衍生物 作用机制 抗肿瘤 抗病毒 消炎止痛 抑制脑神经及血管损伤 

分 类 号：R282.71[医药卫生—中药学]