Efficient Mimics for Elucidating Zaxinone Biology and Promoting Agricultural Applications  

作　　者：Jian You Wang Muhammad Jamil Pei-Yu Lin Tsuyoshi Ota Valentina Fiorilli Mara Novero Randa A.Zarban Boubacar AKountche Ikuo Takahashi Claudio Martinez Luisa Lanfranco Paola Bonfante Angel R.de Lera Tadao Asami Salim Al-Babili 

机构地区：[1]King Abdullah University of Science and Technology,Division of Biological and Environmental Science and Engineering,the BioActives Lab,Thuwal 23955-6900,Saudi Arabia [2]Graduate School of Agricultural and Life Sciences,The University of Tokyo,Tokyo,Japan [3]Department of Life Sciences and Systems Biology,University of Torino,Torino,Italy [4]Universidade de Vigo,Facultade de Quimica and CINBIO,Vigo,Spain

出　　处：《Molecular Plant》2020年第11期1654-1661,共8页分子植物（英文版）

基　　金：the Bill&Melinda Gates Foundation(grant no.OPP1194472);a Competitive Research Grant(CRG2017)to S.A.-B.from King Abdullah University of Science and Technology(KAUST);the Core Research for Evolutional Science and Technology(CREST)Program;the SATREPS Program of the Japan Science and Technology Agency(JST);JSPS Grant-in-Aid for Scientific Research(grant no.18H03939)to T.A.

摘　　要：Zaxinone is an apocarotenoid regulatory metabolite required for normal rice growth and development.In addition,zaxinone has a large application potential in agriculture,due to its growth-promoting activity and capability to alleviate infestation by the root parasitic plant Striga through decreasing strigolactone(SL)production.However,zaxinone is poorly accessible to the scientific community because of its laborious organic synthesis that impedes its further investigation and utilization.In this study,we developed easy-to-synthesize and highly efficient mimics of zaxinone(MiZax).We performed a structure-activity relationship study using a series of apocarotenoids distinguished from zaxinone by different structural features.Using the obtained results,we designed several phenyl-based compounds synthesized with a high-yield through a simple method.Activity tests showed that MiZax3 and MiZax5 exert zaxinone activity in rescuing root growth of a zaxinone-deficient rice mutant,promoting growth,and reducing SL content in roots and root exudates of wild-type plants.Moreover,these compounds were at least as efficient as zaxinone in suppressing transcript level of SL biosynthesis genes and in alleviating Striga infestation under greenhouse conditions,and did not negatively impact mycorrhization.Taken together,MiZax are a promising tool for elucidating zaxinone biology and investigating rice development,and suitable candidates for combating Striga and increasing crop growth.

关 键 词：APOCAROTENOIDS zaxinone zaxinone mimics STRIGOLACTONE STRIGA root parasitic plants 

分 类 号：Q94[生物学—植物学]