Construction of Alkenyl-Functionalized Spirocarbocyclic Scaffolds from Alkyne-Containing Phenol-Based Biaryls via Sequential lodine-Induced Cyclization/Dearomatization and Pd-Catalyzed Coupling of N-Tosylhydrazones  

作　　者：Anjia Liu Kaiming Han Xin-Xing Wu Shufeng Chen Jianbo Wang 

机构地区：[1]Inner Mongolia Key Laboratory of Fine Organic Synthesis,College of Chemistry and Chemical Engineering,Inner Mongolia University,Hohhot,Inner Mongolia 010021,China [2]Beijing National Laboratory of Molecular Sciences(BNLMS),Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education,College of Chemistry,Peking University,Beijing 100871,China

出　　处：《Chinese Journal of Chemistry》2020年第11期1257-1262,共6页中国化学（英文版）

基　　金：This project was generously supported by the National Natural Science Foundation of China(No.21662025);Beijing National Laboratory for Molecular Sciences(No.BNLMS201811).

摘　　要：of main obse rvation and conclusion An efficient strategy for the formation of alkenyl-functionalized spirocarbocyclic scaffolds from alkyne-containing phenol-based biaryls via sequential iodine-induced cyclization/dearomatization and Pd-catalyzed coupling of N-tosylhydrazones is developed.The approach provides various spirocarbocyclic compounds in moderate to excellent yields with good functional tolerance.The results also demonstrate the feasibility for the direct cross-couplings of N-tosyl hydrazones with sterically congested tetrasubstituted alkenyl halides.

关 键 词：COUPLING substituted PHENOL 

分 类 号：O62[理学—有机化学]