二甲双胍对2型糖尿病合并肥胖患者肠道细菌群落结构和功能的影响  

Effects of metformin on intestinal bacterial community structure and function in obese patients with type 2 diabetes mellitus

作　　者：邢英[1] 郑嵘炅[1] 姜春晖[1] 玛依拉·卡哈尔[1] 木胡牙提[1] Xing Ying;Zheng Rongjiong;Jiang Chunhui;Mayila·kahaer;Muhuyati(Department of Endocrinology,Xinjiang Medical University First Affiliated Hospital,Urumqi 830000,China)

机构地区：[1]新疆医科大学第一附属医院综合内四科,乌鲁木齐830000

出　　处：《中华临床营养杂志》2020年第3期170-176,共7页Chinese Journal of Clinical Nutrition

基　　金：新疆维吾尔自治区自然科学基金(2017D01C343)。

摘　　要：目的探究二甲双胍对2型糖尿病合并肥胖患者肠道细菌群落结构和功能的影响。方法选取2型糖尿病合并肥胖患者30例,借助高通量测序手段比较二甲双胍治疗前后肠道菌群多样性、群落结构和功能的差异。结果二甲双胍能够显著增加肠道菌群群落多样性和丰富度,调节肠道菌群群落结构,增强氨基酸代谢、碳水化合物代谢、脂质代谢、丙酸代谢和丁酸代谢等多种代谢功能,同时显著抑制2型糖尿病、胰岛素抵抗以及胰高血糖素信号通路等功能基因的表达。结论二甲双胍可通过影响肠道菌群结构和功能参与降糖过程。Objective To explore the effect of metformin on intestinal bacterial community structure and function in obese patients with type 2 diabetes mellitus.Method Thirty obese patients with type 2 diabetes mellitus were selected to compare the differences of intestinal flora diversity,community structure and function before and after metformin treatment by means of high-throughput sequencing.Result Metformin could significantly increase the diversity and richness of intestinal flora community,regulate the structure of intestinal flora community,enhance a variety of metabolism functions such as amino acid metabolism,carbohydrate metabolism,lipid metabolism,propanoic acid metabolism and butanoate metabolism,and significantly inhibit the expression of functional genes such as type 2 diabetes mellitus,insulin resistance and glucagon signaling pathway.Conclusion Metformin can participate in the hypoglycemic process by affecting the structure and function of intestinal flora.

关 键 词：2型糖尿病 肠道菌群 二甲双胍 

分 类 号：R587.2[医药卫生—内分泌] R589.2[医药卫生—内科学]