调益三焦针灸法对中晚期非小细胞肺癌癌因性疲乏的疗效及免疫功能的影响  

Effects of “Tiaoyi Sanjiao” acupuncture and moxibustion on cancer-induced fatigue and immune function in patients with advanced non-small cell lung cancer

作　　者：李文涛[1] 刘云鹤[1] 潘攀[2] 叶松山 夏颖 刘阿庆[2] 于建春[1] LI Wen-tao;LIU Yun-he;PAN Pan;YE Song-shan;XIA Ying;LIU A-qing;YU Jian-chun(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617)

机构地区：[1]天津中医药大学第一附属医院,天津300381 [2]天津中医药大学,天津301617

出　　处：《针刺研究》2020年第12期1000-1005,共6页Acupuncture Research

基　　金：天津中医药大学第一附属医院“拓新工程”基金项目(No.院201715)。

摘　　要：目的:观察调益三焦针灸法治疗中晚期非小细胞肺癌癌因性疲乏的疗效及对淋巴细胞计数的影响。方法:将符合纳入标准的中晚期非小细胞肺癌癌因性疲乏患者随机分为对照组和治疗组,每组77例。对照组用常规中西药结合治疗,治疗组在对照组治疗的基础上联合调益三焦针灸法(温和灸膻中、中脘、气海、足三里,针刺血海、外关、太冲)治疗。观察两组患者治疗前后的卡氏(KPS)评分、Piper量表评分、淋巴细胞亚群百分比及绝对计数的变化。结果:与治疗前比较,两组患者治疗后KPS评分均明显升高(P<0.05);对照组Piper量表行为维度评分、B细胞的百分比明显下降(P<0.05);治疗组Piper量表行为维度、情绪维度、感觉维度评分及总评分均明显降低(P<0.05),CD3^+T细胞的百分比及CD3^+T细胞、CD4^+T细胞、CD8^+T细胞计数明显升高(P<0.05)。治疗后,与对照组比较,治疗组Piper量表行为维度评分明显下降(P<0.05);B细胞、CD4^+T细胞的百分比和绝对计数上升(P<0.05),CD3^+T细胞计数明显升高(P<0.05)。结论:调益三焦针灸法可明显缓解中晚期非小细胞肺癌患者的疲乏状态,提高生活质量,其作用机制可能是通过调节淋巴细胞数量、改善免疫功能实现的。Objective To observe the therapeutic effect of"Tiaoyi Sanjiao"(regulating and tonifying the triple energizer)acupuncture and moxibustion in the treatment of cancer-related fatigue of advanced non-small cell lung cancer and observe its influence on lymphocyte count.Methods The cancer-related fatigue patients with advanced non-small cell lung cancer who met the inclusive criteria were randomly divided into 2 groups,with 77 cases in each group.Patients in the control group were treated with conventional Chinese and Western medicine.In the treatment group,on the base of the treatment as the control group,"Tiaoyi Sanjiao"acupuncture and moxibustion was applied(mild moxibustion at Danzhong[CV17],Zhongwan[CV12],Qihai[CV6],bilateral Zusanli[ST36],and acupuncture at bilateral Xuehai[SP10],Waiguan[SJ5],Taichong[LR3]).KPS score,Piper scale,percentage and absolute count of lymphocyte subsets of the two groups before and after treatment were observed.Results Compared with pre-treatment,the KPS scores of both groups were significantly increased after treatment(P<0.05);the behavioral dimension score of the Piper scale,and the percentage of B cells of the control group decreased significantly(P<0.05);the behavioral dimension,emotional dimension,sensory dimension scores,and total score of the Piper scale in the treatment group were significantly reduced(P<0.05),while the percentage of CD3^+T cells and absolute counts of CD3^+T cells,CD4^+T cells and CD8^+T cells of the treatment group were significantly increased(P<0.05).After treatment,in comparison with the control group,behavioral dimension score of the Piper scale in the treatment group decreased significantly(P<0.05);the percentage and absolute counts of B cells and CD4^+T cells,the absolute count of CD3^+T cells in the treatment group were up-regulated(P<0.05).Conclusion"Tiaoyi Sanjiao"acupuncture and moxibustion can significantly alleviate the fatigue state and improve the quality of life in patients with advanced non-small cell lung cancer,which may be achieved by regulat

关 键 词：调益三焦针灸法 癌因性疲乏 中晚期非小细胞肺癌 淋巴细胞亚群 绝对计数 

分 类 号：R246[医药卫生—针灸推拿学]