Direct Construction of NOBINs via Domino Arylation and Sigmatropic Rearrangement Reactions  

作　　者：Ji-Wei Zhang Liang-Wen Qi Shaoyu Li Shao-Hua Xiang Bin Tan 

机构地区：[1]School of Chemistry and Chemical Engineering,Harbin Institute of Technology,Harbin,Heilongjiang 150001,China [2]Shenzhen Grubbs Institute and Department of Chemistry,Southern University of Science and Technology,Shenzhen,Guangdong 518055,China [3]Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,Guangdong 518055,China

出　　处：《Chinese Journal of Chemistry》2020年第12期1503-1514,共12页中国化学（英文版）

基　　金：We are grateful for financial support from the National Natural Science Foundation of China(Nos.21772081,21825105,21801117);Guangdong Provincial Key Laboratory of Catalysis(No.2020B121201002);the Guangdong Innovative Program(No.2019BT02Y335);the Shenzhen Special Funds(No.JCYJ2018030-5123508258);Shenzhen Nobel Prize Scientists LaboratoryProject(No.C17213101).

摘　　要：of main observation and conclusion Privileged 2-amino-2,-hydroxy-l/l,-binaphthyl(NOBIN)frameworks were constructed through a novel domino arylation of naphthylhydroxylamines with diarylhalonium salts and sigmatropic rearrangement in a transition metal-free fashion.This protocol bears broad substrate generality and proceeds under mild reaction conditions,affording diversified NOBINs in high efficiency with absolute regiocontrol during the rearrangement process.Optically active product was accessible by chiral A/-heterocyclic carbene-catalyzed kinetic resolution in one pot or diastereoselective[3,3]-rearrangement guided by a removable chiral auxiliary.Remarkably,diarylchloronium and diarylbrominium salts have been employed as arylation reagents for the first time in assembling such representative biaryl frameworks.

关 键 词：process. REARRANGEMENT SALTS 

分 类 号：O621.251[理学—有机化学]