Iridium-Catalyzed Enantioselective C(sp^3)-H Borylation of Cyclobutanes  

作　　者：Xiang Chen Lili Chen Hongliang Zhao Qian Gao Zhenlu Shen Senmiao Xu 

机构地区：[1]College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310014,China [2]State Key Laboratory for Oxo Synthesis and Selective Oxidation,Center for Excellence in Molecular Synthesis,Suzhou Research Institute,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000,China [3]Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education,Hangzhou Normal University,Hangzhou 311121,China

出　　处：《Chinese Journal of Chemistry》2020年第12期1533-1537,共5页中国化学（英文版）

基　　金：We thank the National Natural Science Foundation of China(21573262,21776260,21873261,and 91956116);the Natural Science Foundation of Jiangsu Province(BK20170422)for thegenerous support.

摘　　要：of main observation and conclusion We herein report the first example of iridium-catalyzed enantioselective C(sp^3)-H borylation of cyclobutanes using benzoxazoline as the directing group.The combination of a chiral bidentate boryl ligand and an iridium precursor has found to effectively catalyze C(sp)-H borylation to afford a variety of cyclobutylboronates with good to excellent enantioselectivities.We also demonstrate the synthetic utility of the current method by converting the stereogenic C—B bond to other functionalities.

关 键 词：group. BUTANE BORON 

分 类 号：O62[理学—有机化学]