Highly Regio-,Diastereo-,and Enantioselective Assembly of Azepino[2,3-b]indoles via Palladium-Catalyzed[4+3]Cycloaddition  

作　　者：Wu-Lin Yang Zesheng Huang Yang-Zi Liu Xingxin Yu Wei-Ping Deng 

机构地区：[1]Shanghai Key Laboratory of New Drug Design ond School of Pharmacy,East China University of cience and Technology.130 Meilong Rood,Shanghai 200237,China [2]Key Laboratory of the Ministry of Education for Advanced Catalysis Materials,Department of Chemistry,Zhejiang Normal University,Jinhua,Zhejiang 321004,China

出　　处：《Chinese Journal of Chemistry》2020年第12期1571-1574,共4页中国化学（英文版）

基　　金：This work is supported by the National Natural Science Foundation of China(Nos.21772038,21971062,and 21901072);Shanghai Sailing Program(No.18YF140560).

摘　　要：of main observation and conclusion A palladium-catalyzed asymmetric[4+3]cycloaddition of trimethylenemethanes and indoline-derived aza-dienes has been developed.The potential[3+2]side pathway was completely suppressed in the process.This protocol provides an efficient access to azepino[2,3-b]indoles bearing two vicinal stereocenters in generally excellent diastereo-and enantioselectivities(up to>20:1 dr,99% ee).

关 键 词：process. STEREO PALLADIUM 

分 类 号：O641.4[理学—物理化学] O621.251[理学—化学]