吲哚美辛、生长抑素单用或联用预防ERCP术后胰腺炎的临床研究  

Clinical Study of Indomethacin and Somatostatin Alone or in Combination to Prevent Pancreatitis after ERCP

作　　者：邱萍[1] 静艳 李恺 李兴[1] 文萍[1] 文剑波[1] 龚敏[1] QIU Ping;JING Yan;LI Kai;LI Xing;WEN Ping;WEN Jianbo;GONG Min(People's Hospital of Pingxiang City,Pingxiang Jiangxi 337000,China;Jiangxi Medical College of Nanchang University,Nanchang Jiangxi 330006,China.)

机构地区：[1]萍乡市人民医院,江西萍乡337000 [2]南昌大学江西医学院,南昌330006

出　　处：《药品评价》2020年第20期17-19,共3页Drug Evaluation

基　　金：江西省卫生健康委科技计划项目(20204374)。

摘　　要：目的:探讨吲哚美辛、生长抑素单用或联用预防内镜逆行胰胆管造影(ERCP)术后胰腺炎的临床效果。方法:选择2020年1月—2020年6月拟在本院行ERCP术的患者100例为研究对象,按随机数字表法分为A组、B组、C组、D组,各25例。A组术前行常规基础药物治疗,在此基础上,B组行吲哚美辛治疗,C组行生长抑素治疗,D组行吲哚美辛联合生长抑素治疗。对比各组术后胰腺炎发生率和术后3 h、12 h血清淀粉酶、脂肪酶、C反应蛋白(CRP)及腹痛评分。结果:B组、C组、D组术后胰腺炎发生率低于A组,差异有统计学意义(P<0.05);术后3 h、12 h血清淀粉酶、脂肪酶、CRP的水平顺序为:D组<B组<C组<A组,差异有统计学意义(P<0.05);术后3 h、12 h视觉模拟评分法(VAS)评分顺序为:D组<B组<C组<A组,差异有统计学意义(P<0.05)。结论:吲哚美辛、生长抑素联合使用能有效预防ERCP术后胰腺炎发生,降低血清淀粉酶、脂肪酶、CRP水平,减轻腹痛程度。Objective:To investigate the clinical effect of indomethacin and somatostatin on the prevention of pancreatitis after ERCP.Methods:From January 2020 to June 2020,100 patients scheduled for ERCP in our hospital were selected and randomly divided into group A,group B,group C and group D,25 cases in each group.Group a received routine basic drug treatment before operation.On this basis,group B received indomethacin treatment,group C received somatostatin treatment,and group D received indomethacin combined with somatostatin treatment.The incidence of postoperative pancreatitis,serum amylase,lipase,C-reactive protein(CRP)and abdominal pain score at 3 h and 12 h after operation were compared.Results:The incidence of postoperative pancreatitis in group B,group C and group D was lower than that in group A,the difference was statistically significant(P<0.05);the order of serum amylase,lipase and CRP levels at 3 h and 12 h after operation was as follows:group D<group B<group C<group A,the difference was statistically significant(P<0.05);3 h and 12 h after operation,the difference was statistically significant(P<0.05)H visual analogue scale(VAS)score order:group D<group B<group C<group A,the difference was statistically significant(P<0.05).Conclusion:The combined use of indomethacin and somatostatin can effectively prevent the occurrence of pancreatitis after ERCP,reduce the levels of serum amylase,lipase and CRP,and reduce the degree of abdominal pain.

关 键 词：内镜逆行胰胆管造影 吲哚美辛 生长抑素 胰腺炎 

分 类 号：R969.4[医药卫生—药理学] R657.51[医药卫生—药学]