U系列新型合成阿片类物质的质谱特征  

Mass Fragmentation Characteristics of U-Drugs Novel Synthetic Opioids

作　　者：钱振华[1] 贾薇[2] 花镇东[2] 刘翠梅[2] QIAN Zhen-hua;JIA Wei;HUA Zhen-dong;LIU Cui-mei(Institute of Forensic Science Ministry of Public Security,Beijing 100038,China;Drug Intelligence and Forensic Center of the Ministry of Public Security,Beijing 100193,China)

机构地区：[1]公安部物证鉴定中心,北京100038 [2]公安部禁毒情报技术中心,北京100193

出　　处：《质谱学报》2021年第1期84-92,I0004,共10页Journal of Chinese Mass Spectrometry Society

摘　　要：采用气相色谱-质谱联用法(GC-MS)和超高效液相色谱-串联四极杆飞行时间质谱法(UPLC-QTOF MS)分析国际药物滥用市场最新流行的U系列新型合成阿片类物质,分别在电子轰击源(EI)和电喷雾正离子(ESI^+)-碰撞诱导解离(CID)模式下采集数据。EI模式下,U系列新型合成阿片类物质的分子离子峰丰度较低,几乎都出现了m/z 84、125(或者m/z 112、153)的峰;ESI^+模式下,U系列新型合成阿片类物质的碎裂主要发生在酰胺基的两端及内部,二级质谱图中除准分子离子峰([M+H]^+)外,至少还会出现5个峰,分别为离子碎片A~E,其中A为基峰,A比B的质量数多80,C比D的质量数多28,E的精确质量数为81.069 9。通过总结该类物质在两种模式下获得的碎片离子与分子结构的关系,推测其可能的碎裂途径,并归纳了通过谱图推导未知U系列新型合成阿片类物质结构的方法,可为该类物质的鉴定提供参考。The abuse of new psychoactive substances(NPS)has been increasing dramatic worldwide since late 2000 s.By the end of 2019,more than 900 NPS had been reported to the United Nations Office for Drugs and Crime(UNODC).NPS can be subdivided in different groups,such as synthetic cannabinoids,synthetic cathinones,or novel synthetic opioids(NSOs).Although the total number of emerging NPS has slowly decreased in recent years,more and more NSOs have appeared on the illicit drugs market.According to the European Monitoring Centre for Drugs and Drug Addiction(EMCDDA)European Drug Report 2017,NSOs have been involved in overdose drug related deaths in some parts of Europe and North America,these compounds have been found in 82%of fatal overdoses.This phenomenon,related to the misuse of prescription opioids,has been dubbed an"opioids crisis".Among NSOs are U-47700,U-49900,or U-48800,and so on,which belong to the so-called U-drugs and are structurally non-related to classical opioids such as morphine and fentanyl.U-drugs substances were originally synthesized in the 1970 s and 1980 s by the Upjohn Company,a pharmaceutical company from Kalamazoo,MI,USA,and appeared on the illicit drug market since 2014.Since U-47700 was internationally controlled in 2017,compounds with similar chemical structures,adapted from the original patented compounds,have emerged across the illicit synthetic drugs market.An increasing number of deaths have been associated with the use of U-drugs novel synthetic opioids,particularly in North America.In 2015-2019,a series of six U-drugs novel synthetic opioids were identified by means of ultra performance liquid chromatography-quadrupole time-of-flight-mass spectrometry(UPLC-QTOF MS),gas chromatography-mass spectrometry(GC-MS),and nuclear magnetic resonance spectroscopy(NMR)in China.The mass-spectral fragmentations of these compounds following electron ionization(EI)and electrospray ionization(ESI)under collision-induced dissociation(CID)mode were studied.Compounds were analyzed on Aglient DB-5 MS column(30 m

关 键 词：气相色谱-质谱(GC-MS) 超高效液相色谱-串联四极杆飞行时间质谱(UPLC-QTOF MS) U系列新型合成阿片类物质 新精神活性物质 碎裂途径 

分 类 号：O657.63[理学—分析化学]