丙型肝炎病毒感染患者凝血功能改变的研究  

Study on the changes of coagulation function in patients with hepatitis C virus

作　　者：葛玉梅[1] 楼楚冰 周永列[1] 胡诗卉 杨芳芳 GE Yu-mei;LOU Chu-bing;ZHOU Yong-lie;HU Shi-hui;YANG Fang-fang(Center of Clinical Laboratory Medicine,Zhejiang Provincial People’s Hospital,People’s Hospital Affiliated to Hangzhou Medical College,Hangzhou,Zhejiang 310014,China;不详)

机构地区：[1]浙江省人民医院临床医学检验中心,杭州医学院附属人民医院,浙江杭州310014 [2]台州学院医学院,浙江台州318000 [3]温州医科大学检验医学院生命科学院,浙江温州325035

出　　处：《中国卫生检验杂志》2020年第24期2991-2993,共3页Chinese Journal of Health Laboratory Technology

基　　金：浙江省人民医院优秀青年科研启动基金(ZRY2018-B004)。

摘　　要：目的探讨丙型肝炎病毒(hepatitis C virus,HCV)感染患者凝血功能变化情况,以及血小板与凝血功能之间的关系。方法选择2015年1月-2018年12月浙江省人民医院慢性丙型肝炎患者42例作为研究组,另选择58例本院健康体检者作为对照组。比较2组之间凝血功能各项指标;讨论研究组血小板和凝血功能指标之间的关系。结果丙型肝炎病毒感染组与对照组PT、INR、APTT、APTTR、FIB差异有统计学意义(P <0.05),TT差异无统计学意义(P>0.05)。血小板与PT、APTT、TT呈负相关(r值分别为-0.551、-0.556、-0.372,P <0.05),与FIB呈正相关(r=0.530,P <0.05)。结论抗丙型肝炎病毒的治疗和监测中应重视凝血功能和血小板数量检测。Objective To investigate the changes of coagulation function in patients with hepatitis C virus infection and the relationship between platelets and coagulation function.Methods From January 2015 to December 2018,42 patients with chronic hepatitis C were selected as the research group,and 58 health subjects were selected as the control group in Zhejiang Provincial People’s Hospital.The coagulation function indicators between the two groups were compared to discuss the relationship between platelets and coagulation function in the research group.Results There was statistical significance on the differences in PT,INR,APTT,APTTR and FIB between the HCV infection group and the control group(P<0.05),and no statistical significance on the differences in TT(P>0.05).Conclusion Coagulation function and platelet count should be emphasized in the treatment and monitoring of anti—hepatitis C virus.

关 键 词：丙型肝炎病毒 凝血功能 血小板 

分 类 号：R512.63[医药卫生—内科学]