MSTN基因在动物生产中的研究进展  

Research progress of MSTN gene in animal production

作　　者：董诗琳 张梦帆 李耀东 Dong Shilin;Zhang Mengfan;Li Yaodong(College of Life Science and Engineering,Northwest Minzu University,Gansu Lanzhou 730030)

机构地区：[1]西北民族大学生命科学与工程学院,甘肃兰州730030

出　　处：《现代畜牧兽医》2020年第12期61-64,共4页Modern Journal of Animal Husbandry and Veterinary Medicine

基　　金：西北民族大学中央高校基本科研业务费资金资助项目(31920190202-02、31920180005);西北民族大学引进人才科研项目(Z15124)。

摘　　要：肌肉生长抑制素(MSTN)是调节骨骼肌发育的因子之一,属于TGF-β超家族的成员,能够对肌肉生长起负调控作用。该基因在骨骼肌中广泛表达,基因缺失或突变能够导致动物体表现出"双肌"表型。在畜牧生产中,MSTN基因的多肽可以作为选择肌肉性状的分子标记。文章对MSTN基因的结构特点、生物学功能、作用机制以及在动物生产中的应用进行阐述,展望该基因的研究前景。Myostatin(MSTN) is one of the factors that regulate skeletal muscle development. It is a member of the TGF-β superfamily and can negatively regulate muscle growth. The gene is widely expressed in skeletal muscle, and deletion or mutation can cause animals to exhibit a ’bicuscular’ phenotype. In livestock production, the polymorphism of MSTN gene can be used as a molecular marker for the selection of muscle traits. In the paper, the structural characteristics, biological function, mechanism of action and its application in animal production of MSTN gene are reviewed, and the research prospect of MSTN gene is prospected.

关 键 词：肌肉生长抑制素 骨骼肌 TGF-Β超家族 研究进展 

分 类 号：S813[农业科学—畜牧学]