血清CD146与腹膜透析患者腹主动脉钙化的相关性研究  

Correlation between serum CD146 and abdominal aortic calcification in patients with peritoneal dialysis

作　　者：曹婧媛[1] 赵诗竹 卢国元[2] CAO Jingyuan;ZHAO Shizhu;LU Guoyuan(Department of Nephrology,Taizhou City People′s Hospital in Jiangsu Province,Taizhou,Jiangsu,225300;Department of Nephrology,The First Affiliated Hospital of Soochow University,Suzhou,Jiangsu,215000)

机构地区：[1]江苏省泰州市人民医院肾内科,江苏泰州225300 [2]苏州大学附属第一医院肾内科,江苏苏州215000

出　　处：《实用临床医药杂志》2020年第23期73-77,共5页Journal of Clinical Medicine in Practice

摘　　要：目的分析血清CD146水平与腹膜透析(PD)患者腹主动脉钙化(AAC)的相关性。方法收集纳入的PD患者的临床资料及实验室相关资料,采用酶联免疫吸附实验测定血清CD146水平,采用腹部CT评估AAC发生情况及严重程度。结果纳入符合标准的PD患者133例,其中AAC者74例(55.6%)。发生AAC的PD患者中,重度AAC者30例(40.5%),非重度AAC者44例(59.5%)。合并AAC的PD患者血清CD146水平高于非AAC者,差异有统计学意义(P<0.001),重度AAC患者血清CD146高于非重度AAC组,差异有统计学意义(P=0.021)。多因素Logistic回归分析显示,PD患者年龄增长、腹透龄延长、血磷升高、CD146升高与AAC的发生风险增高相关(P<0.05或P<0.01);PD患者白蛋白升高时发生重度AAC的风险降低(P=0.015),CD146升高与重度AAC的发生风险增高相关(P=0.005)。结论血清CD146升高与PD患者AAC及重度AAC的发生风险增高相关,CD146可作为早期预警PD患者发生AAC的有效指标。Objective To analyze the correlation between CD146 and abdominal aortic calcification(AAC)in patients with peritoneal dialysis(PD).Methods Clinical and laboratory materials of patients with PD were collected,and the level of serum CD146 was detected by enzyme-linked immunosorbent assay.Abdominal computed tomography(CT)was used to evaluate the incidence and severity of AAC.Results Totally 133 eligible PD patients were selected,including 74 cases with AAC(55.6%).Among PD patients with AAC,30 cases(40.5%)had severe AAC and 44 cases(59.5%)had non-severe AAC.The serum CD146 level of PD patients with AAC was significantly higher than that of non-AAC patients(P<0.001),while the serum CD146 level of patients with severe AAC was significantly higher than that of patients with non-severe AAC(P=0.021).Multivariate Logistic regression analysis showed that increasing age,prolonged duration of peritoneal dialysis,increasing serum phosphorus and increasing CD146 level were associated with the increased risk of AAC(P<0.05 or P<0.01).The risk of severe AAC reduced significantly when albumin increased in PD patients(P=0.015).The increased CD146 level was associated with an increased risk of severe AAC(P=0.005).Conclusion Serum CD146 is associated with an increased risk of AAC and severe AAC in PD patients,and the level of serum CD146 could be used as an early indicator of AAC in PD patients.

关 键 词：CD146 腹膜透析 腹主动脉钙化 白蛋白 慢性肾脏病 

分 类 号：R459.5[医药卫生—治疗学] R543.1[医药卫生—临床医学]