老年原发性高血压患者生理指标及氧化应激指标的变化和意义  

Changes of physiological indexes and oxidative stress indexes in elderly patients with essential hypertension and their significance

作　　者：刘欢[1] 刘永霞[1] 刘燕[1] 赵妮 LIU Huan;LIU Yongxia;LIU Yan;ZHAO Ni(Department of Transfusion,Affiliated Hospital of Yan′an University,Yan′an,Shaanxi,716000)

机构地区：[1]延安大学附属医院输血科,陕西延安716000

出　　处：《实用临床医药杂志》2020年第23期88-91,共4页Journal of Clinical Medicine in Practice

摘　　要：目的探讨老年原发性高血压(EH)患者臂踝脉搏波传导速度(baPWV)、超敏C反应蛋白(hs-CRP)、脂蛋白相关磷脂酶A2(Lp-PLA2)及氧化应激指标的变化和意义。方法将170例老年EH患者分为硬化组80例和对照组90例。比较2组的baPWV、hs-CRP、Lp-PLA2、超氧化物歧化酶(SOD)、丙二醛(MDA)及血脂指标水平,并分析baPWV、hs-CRP、Lp-PLA2、SOD、MDA的相关性。结果硬化组血清甘油三酯(TG)、总胆固醇(TC)、低密度值蛋白胆固醇(LDL-C)、baPWV、hs-CRP、Lp-PLA2、MDA高于对照组,差异均有统计学意义(P<0.05)。硬化组血清SOD低于对照组,差异有统计学意义(P<0.05);老年EH伴有颈动脉粥样硬化患者baPWV、hs-CRP、Lp-PLA2、MDA与颈动脉内膜中膜厚度(IMT)呈显著正相关,SOD与IMT呈显著负相关。结论老年EH伴有颈动脉粥样硬化的患者baPWV、hs-CRP、Lp-PLA2、MDA水平增高,SOD降低,或可促进颈动脉粥样硬化发展。Objective To investigate the changes of brachial-ankle pulse wave velocity(baPWV),hypersensitive C-reactive protein(hs-CRP),lipoprotein-associated phospholipase A2(LP-PLA2)as well as oxidative stress indexes in elderly patients with essential hypertension(EH)and their significance.Methods A total of 170 elderly patients with EH were divided into sclerosis group(n=80)and control group(n=90).The levels of baPWV,hs-CRP,LP-PLA2,superoxide dismutase(SOD),malondialdehyde(MDA)and blood lipid in the two groups were compared,and the correlations among baPWV,hs-CRP,LP-PLA2,SOD and MDA were analyzed.Results Serum triglyceride(TG),total cholesterol(TC),low density lipoprotein-cholestero(LDL-C),baPWV,hs-CRP,LP-PLA2 and MDA in the sclerosis group were significantly higher than those in the control group(P<0.05).The serum SOD level of the sclerosis group was significantly lower than that of the control group(P<0.05).In the elderly EH patients with carotid atherosclerosis,baPWV,hs-CRP,LP-PLA2 and MDA presented significant positive correlations with intima-media thickness(IMT),while SOD and IMT presented a significant negative correlation.Conclusion In the elderly EH patients with carotid atherosclerosis,the levels of baPWV,hs-CRP,LP-PLA2 and MDA are increased and SOD is decreased,which may promote the development of carotid atherosclerosis.

关 键 词：原发性高血压 臂踝脉搏波传导速度 超敏C反应蛋白 脂蛋白相关磷脂酶A2 氧化应激 

分 类 号：R544.1[医药卫生—心血管疾病] R446.11[医药卫生—内科学]