微通道反应器合成二缩三乙二醇二硝酸酯的工艺  

Synthesis of triethylene glycol dinitrate in a micro-channel reactor

作　　者：刘卫孝[1] 高福磊[1] 朱勇[1] 汪伟[1] 李斌栋[2] 陈斌[1] 汪营磊[1] LIU Wei-xiao;GAO Fu-lei;ZHU Yong;WANG Wei;LI Bin-dong;CHEN Bin;WANG Ying-lei(Xi'an Modern Chemistry Research Institute,Xi'an 710065,China;School of Chemical and Engineering,Nanjing University of Science and Technology,Nanjing 210094,China)

机构地区：[1]西安近代化学研究所,陕西西安710065 [2]南京理工大学化工学院,江苏南京210094

出　　处：《高校化学工程学报》2020年第6期1430-1435,共6页Journal of Chemical Engineering of Chinese Universities

基　　金：国家自然科学基金(21303133,21875185)。

摘　　要：为了开发硝酸酯安全、高效的合成新技术,开展微通道反应器中二缩三乙二醇二硝酸酯合成工艺研究,考察水浴温度、物料比以及平均停留时间对反应收率和纯度的影响。结果表明,微通道反应器合成二缩三乙二醇二硝酸酯的最佳工艺条件为:水浴温度25℃,硝酸、硫酸与二缩三乙二醇摩尔比1:0.67:0.3,平均停留时间16.3 s;与传统工艺相比,微通道反应合成工艺具有硝酸用量省、在线量小、停留时间短、收率高等优点。In order to develop a safe and high efficiency technique for nitrate ester synthesis,a synthetic process of triethylene glycol dinitrate was studied in a micro-channel reactor.The effects of water bath temperature,material ratio and average residence time on the yield and purity of the product were investigated,the results show that the optimal water bath temperature is 25℃,the optimal material ratio between nitric acid,sulphuric acid and triethylene glycol is 1:0.67:0.3,and the optimal average residence time is 16.3 s.Comparing to conventional synthetic processes,the process has advantages such as less nitric acid usage,lower reacting material quantity,shorter residence time and higher yield.

关 键 词：微通道反应器 硝酸酯 二缩三乙二醇二硝酸酯 硝化工艺 

分 类 号：O626.4[理学—有机化学]