MRI-DWI技术联合血清PSA、CEA检测在前列腺癌早期诊断中的应用价值  

Application Value of MRI-DWI Combined with Serum PSA and CEA Detection in the Early Diagnosis of Prostate Cancer

作　　者：刘晓东[1] 李京龙[2] 李丽梅[3] 王东[4] 史文宗[5] 齐铮琴[1] LIU Xiao-dong;LI Jing-long;LI Li-mei;WANG Dong;SHI Wen-zong;QI Zheng-qin(First Department of Ultrasonic Diagnosis,Qinhuangdao First Hospital,Qinhuangdao 066000,Henan Province,China;Nuclear Magnetic Field,Qinhuangdao First Hospital,Qinhuangdao 066000,Henan Province,China;Department of Pain,Qinhuangdao First Hospital,Qinhuangdao 066000,Henan Province,China;First Department of Laboratory Medicine,Qinhuangdao First Hospital,Qinhuangdao 066000,Henan Province,China;Department of Medical Information Statistics,Qinhuangdao First Hospital,Qinhuangdao 066000,Henan Province,China)

机构地区：[1]秦皇岛市第一医院超声诊断一科,河北秦皇岛066000 [2]秦皇岛市第一医院放射科,河北秦皇岛066000 [3]秦皇岛市第一医院疼痛科,河北秦皇岛066000 [4]秦皇岛市第一医院检验一科,河北秦皇岛066000 [5]秦皇岛市第一医院医疗信息统计室,河北秦皇岛066000

出　　处：《中国CT和MRI杂志》2021年第2期114-117,共4页Chinese Journal of CT and MRI

基　　金：秦皇岛市科技支撑计划项目(202004A124)。

摘　　要：目的探究磁共振弥散加权成像(MRI-DWI)技术联合血清前列腺特异性抗原(PSA)、癌胚抗原(CEA)检测在前列腺癌(PCa)早期诊断中的应用价值。方法以2019年1月至2020年8月在我院治疗的PCa患者86例为研究组,并以同期前列腺良性疾病患者58例为对照组。比较两组血清PSA、CEA水平及表观扩散系数(ADC)值、指数化表观扩散系数(EADC)值。采用ROC曲线分析MRI-DWI技术联合血清PSA、CEA检测对前列腺癌的诊断价值。结果研究组血清PSA、CEA水平及EADC值均高于对照组,研究组ADC低于对照组(P<0.05);联合检测诊断PCa的曲线下面积(AUC)大于血清PSA、CEA水平及MRIDWI参数单独检测(P<0.05);联合检测诊断PCa的灵敏度高于CEA、EADC,特异度高于PSA、ADC,准确度高于CEA、ADC(P<0.05)。结论PCa患者血清PSA、CEA水平高于前列腺良性疾病患者,MRI-DWI参数也与良性疾病患者存在差异,MRI-DWI参数联合血清PSA、CEA检测对PCa具有诊断价值。Objective To explore the application value of diffusion-weighted MR imaging(MRI-DWI)combined with serum prostate-specific antigen(PSA)and carcinoembryonic antigen(CEA)detection in the early diagnosis of prostate cancer(PCa).Methods A total of 86 PCa patients who were treated in the First Hospital of Qinhuangdao from January 2019 to August 2020 were enrolled as a study group,while 58 patients with benign prostate diseases in the same period were enrolled as a control group.The levels of serum PSA and CEA were compared between the two groups.MRI-DWI results in both groups were analyzed.The apparent diffusion coefficient(ADC)and exponential apparent diffusion coefficient(EADC)values were compared between the two groups.The diagnostic value of MRI-DWI combined with serum PSA and CEA detection for PCa was analyzed by ROC curves.The diagnostic sensitivity,specificity and accuracy of combined detection and single detection for PCa were compared.Results The serum PSA and CEA levels in the study group were higher than those in the control group(P<0.05).ADC of the study group was lower than that of the control group(P<0.05).ROC curve analysis showed that the AUC of combined detection for diagnosis of PCa was greater than that of serum PSA,CEA levels,and MRI-DWI parameters alone(P<0.05).The diagnostic sensitivity of combined detection for PCa was higher than that of CEA and EADC,specificity was higher than that of PSA and ADC,and accuracy was higher than that of CEA and ADC(P<0.05).Conclusion The levels of serum PSA and CEA in PCa patients were higher than those in patients with benign prostate diseases.There were differences in MRI-DWI parameters between PCa patients and those with benign diseases.MRI-DWI parameters combined with serum CEA and PSA detection are of diagnostic value for PCa.

关 键 词：磁共振弥散加权成像 前列腺特异性抗原 癌胚抗原 前列腺癌 早期诊断 

分 类 号：R445.2[医药卫生—影像医学与核医学] R737.25[医药卫生—诊断学]