[(6-取代-嘧啶-4-基氧)苯基]-3-甲氧基-丙烯酸甲酯的合成与抑菌活性  

Synthesis and Antibacterial Activity of[(6-substituted-pyrimidin-4-oxo)phenyl]-3-methoxy-methyl Acrylate

作　　者：陶乐[1] 李玉江[1] 郭晓河[1] 王强[1] 董黎红[1] 张倩 TAO Le;LI Yujiang;GUO Xiaohe;WANG Qiang;DONG Lihong;ZHANG Qian(High&New Technology Research Center of Henan Academy of Sciences,Zhengzhou 450002,China)

机构地区：[1]河南省科学院高新技术研究中心,郑州450002

出　　处：《河南科学》2020年第12期1926-1930,共5页Henan Science

基　　金：河南省科技创新杰出青年基金资助项目(094100510019);河南省基础与前沿技术研究项目(162300410006);河南省科技攻关计划项目(092102310021);河南省科学院基本科研费项目(200602007)。

摘　　要：以邻羟基苯乙酸为起始原料,合成了新型结构[(6-取代-嘧啶-4-基氧)苯基]-3-甲氧基-丙烯酸甲酯类化合物.化合物的结构经1H NMR、13C NMR、HRMS确证.生物活性测试表明,合成的新型化合物具有非常好的抑制黄瓜枯萎病菌、花生褐斑病菌、苹果轮纹病菌、小麦纹枯病菌、玉米小斑病菌、西瓜炭疽病菌、水稻恶苗病菌活性.The novel[(6-substituted-pyrimidin-4-methoxy)phenyl]-3-methoxy-methyl acrylates were synthesized with O-hydroxyphenylacetic acid as starting material.The products were characterized by 1H NMR,13C NMR,HRMS.The bioactivity tests showed that the new compounds had very good activities against Fusarium oxysporum,Cercospora arachidicola,Physalospora piricola Rhizoctonia cerealis,Alternaria maydis,Colletotrichum gloeosporioides and Fusarium oxysporum.

关 键 词：嘧啶 甲氧基丙烯酸甲酯 抗病菌活性 嘧菌酯 

分 类 号：O626[理学—有机化学]