尿酸钠晶体的研究进展  

Research Progress of Monosodium Urate Monohydrate Crystals

作　　者：田甜 李泽芬 徐家跃 TIAN Tian;LI Zefen;XU Jiayue(Institute of Crystal Growth,School of Materials Science and Engineering,Shanghai Institute of Technology,Shanghai 201418,China)

机构地区：[1]上海应用技术大学材料科学与工程学院,晶体生长研究所,上海201418

出　　处：《硅酸盐学报》2020年第12期1944-1952,共9页Journal of The Chinese Ceramic Society

基　　金：国家自然科学基金(51972208)资助。

摘　　要：目前国内对于痛风的治疗研究仍集中在医药领域,主要通过药物治疗和针灸治疗缓解患者的疼痛,对尿酸钠结晶机理研究关注较少。从原理上进行分析,痛风是尿酸钠溶质在体液循环中达到过饱和时的结晶表现。从材料学的角度出发,阐述了尿酸钠晶体的结构、形貌、体外制备方法和抑制手段等方面的研究进展,并提出了未来可进一步开展研究的方向。Gout is a term given to the disorder of uric acid metabolism, which results from the deposition of crystals of monosodium urate monohydrate in various connective tissues. Recent domestic researches on the treatment of gout still focus on the development and application of medicine, mainly through drug treatment and acupuncture to relieve the pain of patients. However, less attention is paid to the mechanism of monosodium urate monohydrate crystallization. In principle, gout is the crystallization of monosodium urate solute when it reaches supersaturation in the body fluid circulation. This review, from the perspective of materials, represented recent research work on the structure, morphology, in vitro preparation method and inhibition method of monosodium urate monohydrate crystals, and put forward the direction of further research in the future.

关 键 词：痛风 尿酸钠晶体 晶体生长 抑制机理 

分 类 号：O782[理学—晶体学]