PCC0104007在精神分裂症大鼠模型中的药学研究  

Efficacy of PCC0104007 in Rat Model of Schizophrenia

作　　者：岳馨 刘如梦 朱晓音[1] 田京伟[1] YUE Xin;LIU Ru-meng;ZHU Xiao-yin;TIAN Jing-wei(School of Pharmacy,Key Laboratory of Molecular Pharmacology and Drug Evaluation(Yantai University),Ministry of Education,Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong,Yantai University,Yantai 264005,China)

机构地区：[1]烟台大学药学院分子药理和药物评价教育部重点实验室,烟台大学新型制剂与生物技术药物研究山东省高校协同创新中心,山东烟台264005

出　　处：《烟台大学学报（自然科学与工程版）》2021年第1期42-47,共6页Journal of Yantai University(Natural Science and Engineering Edition)

基　　金：国家自然科学基金资助项目(81473188);山东省重点项目(2017GSF218106);泰山产业领军人才计划和中国科技部重大新药创制专项(2018ZX09303015)。

摘　　要：为了评估PCC0104007作为精神分裂症治疗剂的潜力,采用MK-801和5-HTP诱导的大鼠模型进行体内药效学研究。结果表明,PCC0104007可减轻MK-801诱导的大鼠高自发活动。PCC0104007可显著抑制5-HTP诱导的甩头反应。在NOR试验和MWM试验中PCC0104007显著改善了MK-801慢性给药引起的认知症状。Golgi染色结果表明,PCC0104007可显著缓解MK-801造成的mushroom树突棘密度降低。认知能力的提高可以通过增加蘑菇棘的数量来实现。PCC0104007与一线抗精神病药物阿立哌唑相比非劣势,是精神分裂症新的候选药物。To assess the potentiality of PCC0104007 as Schizophrenia treatment,MK-801 and 5-HTP induced rat models are used to study the pharmacodynamics in vivo.The results show that PCC0104007 can alleviate MK-801-induced hyperactivity in rats in open filed test,and can significantly inhibit 5-HTP induced head twitch response,and moreover,it improvs the cognitive impairment induced by sub-chronic administration of MK-801 in NOR test and MWM test.Golgi staining shows that PCC0104007 significantly alleviats the reduction of mushroom spine induced by MK-801.The improvement of cognition might achieve by increment of mushroom spines.As a new candidate for schizophrenia,PCC0104007 shows similar efficacy to aripiprazole in rat model of schizophrenia.

关 键 词：精神分裂症 MK-801 认知症状 行为学 

分 类 号：R964[医药卫生—药理学]