PEG-Gemini型非离子表面活性剂的合成及应用  

Synthesis and application of PEG-Gemini non-ionic surfactants

作　　者：花昌林 张锐 左星成 刘芮祺 HUA Changlin;ZHANG Rui;ZUO Xingcheng;LIU Ruiqi(Modern Preparation of Traditional Chinese Medicine,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,Jiangxi,China)

机构地区：[1]江西中医药大学现代中药制剂教育部重点实验室,江西南昌330004

出　　处：《精细化工》2020年第12期2504-2509,共6页Fine Chemicals

基　　金：国家自然科学基金(81560579)。

摘　　要：以1,12-十二醇、油酸、聚乙二醇(300、400、600、800、1000)为原料,合成一系列Gemini型非离子表面活性剂,并采用FTIR、1HNMR和13CNMR对产物进行了结构确证。为了评估Gemini型非离子表面活性剂作为注射用增溶辅料的有效性,在表面张力、增溶性以及溶血活性等方面与Tween80进行了比较。结果表明:二-9(8)PEG1000,二-8(9)-羟基-十八烷酸十二烷基二醇二酯(PODD-1000)的安全有效指数是Tween80的13.34倍,更适用于作为注射剂的增溶辅料。A series of Gemini non-ionic surfactants were synthesized from 1,12-dodecanol,oleic acid and polyethylene glycol(300,400,600,800,1000).The products were confirmed by FTIR,1 HNMR and 13 CNMR.In order to evaluate the effectiveness of Gemini non-ionic surfactants as solubilizing excipients for injection,the surface tension,solubilization and hemolytic activity were compared with those of Tween 80.The results showed that the safety and effective index of bis-9(8)polyethylene glycol 1000,bis-8(9)-hydroxy-octadecanoic acid dodecyl dioldiester(PODD-1000)was 13.34 fold that of Tween80,which is more suitable for solubilizing excipients of injection.

关 键 词：PEG-Gemini型非离子表面活性剂 合成 增溶 溶血 

分 类 号：TQ423.2[化学工程]