非布司他治疗痛风并发高脂血症的临床疗效  

Clinical Efficacy of Febuxostat in the Treatment of Gout Complicated with Hyperlipidemia

作　　者：宁晓璐 NING Xiaolu(Department of Rheumatology and Immunology,Jinzhou Central Hospital,Jinzhou 121000,China)

机构地区：[1]锦州市中心医院风湿免疫科,辽宁锦州121000

出　　处：《中国医药指南》2020年第34期95-96,共2页Guide of China Medicine

摘　　要：目的观察非布司他治疗痛风并发高脂血症的临床疗效。方法我院于2017年7月至2019年1月收治多例痛风患者,于其中选取68例痛风并发高脂血症患者作为研究对象,根据治疗方法将所选患者分为两组(Allop组与Febux组),每组34例。Allop组给予别嘌醇治疗,Febux组给予非布司他治疗。以血尿酸情况、血脂水平评价患者的治疗效果。记录两组不良反应发生率。结果治疗前,两组患者的血尿酸指标、血脂水平无明显差异(P>0.05);治疗后,两组患者的血尿酸指标、血脂水平显著改善,Febux组患者的改善情况优于Allop组,组间对比差异明显(P<0.05)。Febux组患者的不良反应发生率(14.71%)低于Allop组(26.47%),组间对比无明显差异(P>0.05)。结论非布司他治疗痛风并发高脂血症,不良反应发生率低于别嘌醇,但未表现出明显差异,说明其安全性大体相同;非布司他降尿酸、降血脂效果较别嘌醇更好,能够显著改善患者血尿酸指标与血脂水平。Objective To observe the clinical effi cacy of febuxostat in the treatment of gout complicated with hyperlipemia.Methods In our hospital from July 2017 to January 2019,we received a number of patients with gout.Among them,68 patients with gout and hyperlipemia were selected as the study subjects.The selected patients were divided into two groups(Allop group and Febux group)according to the treatment method,34 cases per group.The Allop group was treated with allopurinol and the Febux group was given febuxostat.The patient's treatment eff ect was evaluated by blood uric acid status and blood lipid level.The incidence of adverse reactions was recorded in both groups.Results Before treatment,there was no signifi cant diff erence in serum uric acid index and blood lipid level between the two groups(P>0.05).After treatment,the blood uric acid index and blood lipid level of the two groups were signifi cantly improved,and the improvement of the Febux group was better than that of the Allop group(P<0.05).The incidence of adverse reactions in the Febux group(14.71%)was lower than that in the Allop group(26.47%),and there was no signifi cant diff erence between the groups(P>0.05).Conclusion Febuxostat for the treatment of gout complicated with hyperlipemia,the incidence of adverse reactions is lower than that of allopurinol,but it shows no signifi cant diff erence,indicating that its safety is almost the same;but the eff ect of febuxostat on lowering blood fat is more than allopurinol well,it can signifi cantly improve the patient's blood uric acid index and blood lipid levels.

关 键 词：痛风 高脂血症 非布司他 血尿酸 

分 类 号：R589.7[医药卫生—内分泌]