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作 者:熊琦[1] 杜娟[1] 刘英[1] 陈沛[1] XIONG Qi;DU Juan;LIU Ying;CHEN Pei(Department of Otolaryngology,the First Hospital of Wuhan,Wuhan,Hubei 430022,China)
机构地区:[1]武汉市第一医院耳鼻咽喉科,湖北武汉430022
出 处:《徐州医科大学学报》2020年第12期933-936,共4页Journal of Xuzhou Medical University
基 金:武汉市卫生和计划生育委员会科研项目(WZ16C08)。
摘 要:目的探讨中药足浴联合聚焦超声对变应性鼻炎的治疗效果。方法选择2016年1月—2018年2月于武汉市第一医院就诊行聚焦超声微创治疗的变应性鼻炎患者240例,按随机数字表法分为2组,每组各120例。对照组采用常规药物抗炎治疗及护理,观察组在对照组基础上采用中药足浴治疗。观察比较2组患者治疗后疗效、症状积分及白细胞介素-2(IL-2)、免疫球蛋白E(IgE)、白细胞介素-4(IL-4)的表达情况。结果治疗2周后,观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);2组症状积分的差异有统计学意义(P<0.05);2组IL-4、IgE水平均低于治疗前,IL-2水平高于治疗前,且2组间的差异有统计学意义(P<0.01)。2组患者治疗后Th1细胞分数、Th2细胞分数及Th1/Th2均较治疗前下降,差异有统计学意义(P<0.05);组间比较发现,观察组治疗后Th1细胞分数、Th2细胞分数及Th1/Th2均低于对照组,差异有统计学意义(P<0.05)。结论聚焦超声联合中药足浴治疗变应性鼻炎疗效好,症状改善明显,可降低炎症因子,并提升免疫调节因子,值得在临床上大力推广与应用。Objective To explore the effectiveness of Chinese herbal foot bath combined with focused ultrasound on allergic rhinitis.Methods A total of 240 allergic rhinitis patients who underwent minimally invasive treatment through focused ultrasound in the First Hospital of Wuhan from January 2016 to February 2018 were selected.According to the random number table method,they were divided into two groups(n=120):an observation group and a control group.The control group received conventional anti-inflammatory treatment and nursing care,while the observation group was additionally given foot bath.Both groups were compared for their therapeutic effectiveness,symptom scores,and the expression of interleukin-2(IL-2),IgE,and IL-4.Results After two weeks of treatment,the obsesrvation group presented a remarkably higher effective rate than the control group(P<0.05).There was statistical difference in symptom scores between the two groups(P<0.05).After treatment,both group produced significantly lower levels of IL-4 and IgE and higher levels of IL-2 than those before treatment,and statistical difference was found between the two groups(P<0.01).After treatment,both group produced remarkable decreases in Th1 and Th2 cell percentages and Th1/Th2 ratio compared with those before treatment(P<0.05);the observation group produced remarkable decreases in Th1 and Th2 cell percentages and Th1/Th2 ratio than the control group(P<0.05).Conclusions Focused ultrasound combined with various Chinese herbal foot baths is effective to improve symptoms,which can reduce the levels of inflammatory factors,and stimulate the levels of immune regulatory factors.
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