Flexible electrical stimulation device with Chitosan-Vaseline®dressing accelerates wound healing in diabetes  

作　　者：Xiao-Feng Wang Meng-Lu Li Qing-Qing Fang Wan-Yi Zhao Dong Lou Yan-Yan Hu Jun Chen Xiao-Zhi Wang Wei-Qiang Tan 

机构地区：[1]Department of Plastic Surgery,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,310016,Zhejiang Province,PR China [2]Key Laboratory of Micro-Nano Electronic Devices and Smart Systems of Zhejiang Province,College of Information Science&Electronic Engineering,Zhejiang University,Hangzhou,310027,Zhejiang Province,PR China [3]Innovation Center for Signaling Network,College of Life Sciences,Zhejiang University,Hangzhou,310058,Zhejiang Province,PR China

出　　处：《Bioactive Materials》2021年第1期230-243,共14页生物活性材料（英文）

基　　金：grants from National Natural Science Foundation of China(No.81671918);National Key Research Program of China(2016YFC1101004);Zhejiang Provincial Medical and Healthy Science Foundation of China(No.2018KY874).

摘　　要：The healing process of diabetic wounds is typically disordered and prolonged and requires both angiogenesis and epithelialization.Disruptions of the endogenous electric fields(EFs)may lead to disordered cell migration.Electrical stimulation(ES)that mimics endogenous EFs is a promising method in treating diabetic wounds;however,a microenvironment that facilitates cell migration and a convenient means that can be used to apply ES are also required.Chitosan-Vaseline■gauze(CVG)has been identified to facilitate wound healing;it also promotes moisture retention and immune regulation and has antibacterial activity.For this study,we created a wound dressing using CVG together with a flexible ES device and further evaluated its potential as a treatment for diabetic wounds.We found that high voltage monophasic pulsed current(HVMPC)promoted healing of diabetic wounds in vivo.In studies carried out in vitro,we found that HVMPC promoted the proliferation and migration of human umbilical vein endothelial cells(HUVECs)by activating PI3K/Akt and ERK1/2 signaling.Overall,we determined that the flexible ES-chitosan dressing may promoted healing of diabetic wounds by accelerating angiogenesis,enhancing epithelialization,and inhibiting scar formation.These findings provide support for the ongoing development of this multidisciplinary product for the care and treatment of diabetic wounds.

关 键 词：Diabetic wounds Flexible electronic device Electrical stimulation Chitosan-vaseline■gauze Wound healing 

分 类 号：R587.1[医药卫生—内分泌]