长余辉纳米诊疗剂的设计策略与应用研究进展  

Research Progress on Design Strategy and Application of Persistent Luminescence Nanotheranostics

作　　者：康茹 张绍安 练惠旺 陈星中 李杨 KANG Ru;ZHANG Shao-an;LIAN Hui-wang;CHEN Xing-zhong;LI Yang(School of Physics and Optoelectronic Engineering, Guangdong University of Technology, Guangzhou 510006, China;School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China;School of Optoelectronic Engineering, Guangdong Normal University of Technology, Guangzhou 510665, China)

机构地区：[1]广东工业大学物理与光电工程学院,广东广州510006 [2]广州医科大学生物医学工程系,广东广州511436 [3]广东技术师范大学光电工程学院,广东广州510665

出　　处：《发光学报》2020年第12期1614-1626,共13页Chinese Journal of Luminescence

基　　金：国家自然科学基金(51602063);广东省自然科学基金(2019A030310444);广州市科技计划(2019A1515011688)资助项目。

摘　　要：长余辉纳米材料具有激发/发射分离、成像分辨率高、大面积成像与操作模式便捷等优点,在高灵敏度生物医学光学诊断领域引起了广泛关注。然而,随着诊疗一体化需求的增加,现有长余辉纳米材料功能的单一性阻碍了其在微型化、集成化诊疗上的快速发展。基于此,本综述针对生物医学诊疗集成一体化的长余辉纳米诊疗剂开发,展示了相应的设计策略和合成方法,并指出了长余辉纳米诊疗剂的研究前景、机遇及未来的发展方向。In virtue of the separation of excitation and emission,background-free autofluorescence,large area imaging and convenient operation,persistent luminescence nanoparticles(PLNPs)have attracted widespread attention in the field of optical diagnosis.However,with the increasing demand for integrated diagnosis and treatment,the single function of the existing PLNPs limits their technological breakthroughs in the miniaturized and integrated diagnosis and treatment units.Herein,in this review,PLNPs which can meet the integration requirements of biomedical diagnosis and treatment are discussed.Then the design strategies of developing these nanotheranostics are elaborated.Finally,the research opportunities for PLNPs nanotheranostics are prospected.

关 键 词：长余辉 纳米诊疗剂 生物成像 药物治疗 

分 类 号：O482.31[理学—固体物理]