TPOAb、HbA1c、PLGF及血脂水平对妊娠期糖尿病孕妇妊娠结局的影响  

Effect of TPOAb,HbA1c,PLGF and lipid level on pregnancy outcome in pregnant women with gestational diabetes mellitus

作　　者：尤牧 蔡满红[2] You Mu;Cai Manhong(Department of Obstetrics and Gynecology, Nanjing Post Hospital, Nanjing 210007, China;Department of Obstetrics, Nanjing Maternal and Child Health Hospital, Nanjing 210004, China)

机构地区：[1]南京邮政医院妇产科,南京210007 [2]南京市妇幼保健院产科,南京210004

出　　处：《临床荟萃》2021年第1期54-57,共4页Clinical Focus

基　　金：江苏省自然科学基金资助项目TPOAb、HbA1c、PLGF及血脂水平对妊娠期糖尿病孕妇妊娠结局的影响(BK20171490)。

摘　　要：目的探讨妊娠期糖尿病(GDM)孕妇抗甲状腺过氧化物酶抗体(TPOAb)、糖化血红蛋白(HbA1c)、胎盘生长因子(PLGF)、血脂等水平及意义。方法选取在南京市妇幼保健院治疗的GDM患者180例为观察组;选取同期在南京市妇幼保健院产检的健康产妇180例为对照组。于妊娠24~27周,采集空腹静脉血,检测TPOAb、HbA1c、PLGF及血脂指标,对比两组上述指标水平;记录GDM患者妊娠结局,分析妊娠结局不良患者与妊娠结局正常患者TPOAb、HbA1c、PLGF及血脂指标。结果观察组TPOAb、HbA1c、甘油三酯(TG)水平高于对照组,PLGF水平低于对照组(P<0.05);观察组TPOAb阳性率高于对照组(χ^2=12.394,P<0.01);观察组发生妊娠结局不良56例(31.11%),妊娠结局正常124例(68.89%);妊娠结局不良患者TPOAb、HbA1c、TG水平高于妊娠结局正常患者,PLGF水平低于妊娠结局正常患者(P<0.05);妊娠结局不良患者TPOAb阳性率高于妊娠结局正常患者(χ^2=5.762,P=0.016)。结论GDM孕妇TPOAb、HbA1c、PLGF及TG与健康孕妇存在明显差异,可能对妊娠结局产生不良影响。Objective To investigate the levels and significance of antithyroid peroxidase antibody(TPOAb),hemoglobin A1c(HbA1c),placental growth factor(PLGF)and blood lipid in pregnant women with gestational diabetes mellitus(GDM).Methods A total of 180 GDM patients in Nanjing Maternity and Child Health Care Hospital were selected as observation group.A total of 180 healthy pregnant women who were examined in the above hospital during the same period were selected as control group.Fasting venous blood was collected at 24-27 weeks of gestation,and TPOAb,HbA1c PLGF and lipid indexes were detected and compared between two groups.The pregnancy outcomes of GDM patients were recorded,and TPOAb,HbA1c,PLGF and blood lipid indexes between patients with poor pregnancy outcomes and those with normal pregnancy outcomes were analyzed.Results TPOAb,HbA1c,TG in observation group were higher than those in control group,while PLGF was lower than that in control group(P<0.05);TPOAb positive rate in observation group was higher than that in control group(χ^2=12.394,P<0.01);there were 56 patients(31.11%)with poor pregnancy outcomes and 124 patients(68.89%)with normal pregnancy outcomes in observation group.TPOAb,HbA1c,TG in patients with poor pregnancy outcome were higher than those in patients with normal pregnancy outcome,while PLGF was lower than that in patients with normal pregnancy outcome(P<0.05);TPOAb positive rate of patients with poor pregnancy outcome was higher than that of normal pregnancy outcome(χ^2=5.762,P=0.016).Conclusion There were significant differences in TPOAb,HbA1c,PLGF and TG between GDM pregnant women and healthy pregnant women,which may have some adverse influence on pregnancy outcomes.

关 键 词：糖尿病 妊娠 过氧化物酶类 血红蛋白类 糖基化 胞间信号肽类和蛋白质类 血脂异常 妊娠结局 

分 类 号：R587.1[医药卫生—内分泌]