定量CT骨密度测定在中老年男性中的应用研究  

Bone mineral density measurement with quantitative computed tomography in middle-aged and elderly men

作　　者：李楠 曾静[1,2] 张培 刘贯中[2,3] 李婷 刘敏燕 李春霖 黄先勇[3,4] LI Nan;ZENG Jing;ZHANG Pei;LIU Guanzhong;LI Ting;LIU Minyan;LI Chunlin;HUANG Xianyong(Department of Endocrinology, the Second Medical Center of Chinese PLA General Hospital, Beijing 100853;National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853;Department of Radiology, the Second Medical Center of Chinese PLA General Hospital, Beijing 100853;Department of Health Medicine, the Second Medical Center of Chinese PLA General Hospital, Beijing 100853, China)

机构地区：[1]中国人民解放军总医院第二医学中心内分泌科,北京100853 [2]中国人民解放军总医院国家老年疾病临床医学中心,北京100853 [3]中国人民解放军总医院第二医学中心放射科,北京100853 [4]中国人民解放军总医院第二医学中心健康医学科,北京100853

出　　处：《中国骨质疏松杂志》2021年第1期40-43,共4页Chinese Journal of Osteoporosis

基　　金：国家重点研发计划(2020YFC2004900);军队保健专项科研课题面上项目(19BJZ29);解放军总医院第二医学中心专项科研课题拔尖项目(ZXBJ2003)。

摘　　要：目的探讨定量CT(quantitative computed tomography,QCT)骨密度测定在中老年男性中的应用价值。方法收集常规查体、年龄50岁以上的男性138例。每例患者均进行血清学指标检测、QCT和双能X线吸收检测法(DXA)骨密度测定。结果随年龄增加,QCT骨密度及DXA的股骨颈骨密度均呈下降趋势(P<0.05)。QCT方法检出低骨量69例(50.0%),骨质疏松27例(19.6%),而DXA方法检出骨量减少43例(31.2%),骨质疏松4例(2.9%),两种方法的检出率差异具有明显统计学意义(P<0.01)。在不同年龄组,QCT均比DXA对骨量减少的检出率高,且随年龄增加检出率逐渐升高(P<0.01)。结论中老年男性QCT较DXA骨密度测定的骨量减少检出率更高,随年龄增加检出率增加,QCT的方法可能更适于中老年男性骨质疏松防治过程中的检测。Objective To evaluate the value of bone mineral density(BMD)measurement with quantitative computed tomography(QCT)in middle-aged and elderly men.Methods A total of 138 male patients aged over 50 years were recruited in the routine physical examination.All of them underwent serological tests,QCT,and DXA BMD tests.Results BMD of the femoral neck measured with QCT or DXA decreased along with the increase of age(P<0.05).There were 69 cases(50.0%)of low bone mass and 27 cases(19.6%)of osteoporosis detected with QCT,while 43 cases(31.2%)of low bone mass loss and 4 cases(2.9%)of osteoporosis were detected with DXA.The difference of detection rate between the two method was statistically significant(P<0.01).In the different age groups,the detection rate of bone mass loss with QCT method was higher than that with DXA,and the detection rate gradually increased with age(P<0.01).Conclusion The detection rate of bone loss with QCT in middle-aged and elderly men is higher than that measured with DXA.The detection rate increases with age.Therefore,BMD measurement with QCT may be more suitable for monitoring the prevention and treatment of osteoporosis in middle-aged and elderly men.

关 键 词：定量CT 骨密度 骨质疏松 男性 

分 类 号：R681[医药卫生—骨科学]