不同性别病人血浆FGF23、α-Klotho与冠状动脉钙化和主动脉瓣钙化的关系  

Correlation between Plasma FGF23/α-Klotho and Coronary Artery Calcification and Aortic Valve Calcification in Different Genders Patients

作　　者：冯模强 刘天虎 赵佐芳 余朝萍 龚厚文 蓝亚平 黄瑛 何东泽 FENG Muqiang;LIU Tianhu;ZHAO Zuofang;YU Chaoping;GONG Houwen;LAN Yaping;HUANG Ying;HE Dongze(Chengdu Pidu District People′s Hospital,Chengdu 611730,Sichuan,China)

机构地区：[1]成都市郫都区人民医院,成都611730

出　　处：《中西医结合心脑血管病杂志》2021年第1期101-106,共6页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：四川省医学科研青年创新课题(No.Q17052)。

摘　　要：目的探讨血清纤维细胞生长因子23(FGF23)、α-Klotho水平与冠状动脉钙化(CAC)和主动脉瓣钙化(AVC)的关系。方法选取2018年5月—2019年1月因胸痛在我院确诊或疑似冠状动脉疾病的病人157例,使用128层螺旋CT进行心脏扫描,通过Agatston评分系统对CAC和AVC进行钙化评分,并使用酶联免疫吸附法测量血清FGF23和α-Klotho水平,采用Logistic回归分析法分析FGF23、α-Klotho与CAC、AVC的关系。结果以CAC、AVC作为应变量进行逻辑回归分析,女性病人在调整混杂变量如年龄、肾功能、高血压、使用他汀类药物、利尿剂和钙/磷代谢相关因素后,FGF23(52.5,180.3)pg/mL与CAC有关(P<0.05)。男性病人在调整年龄、肾功能、高血压、使用他汀类药物、利尿剂和钙/磷代谢相关因素后,α-Klotho(561,4859)pg/mL与AVC有关(P<0.05)。男性病人血浆FGF23与CAC、AVC无关,女性病人血浆α-Klotho与CAC、AVC无关。结论在诊断或疑似冠状动脉疾病的受试者中,血清FGF23与女性CAC有关,血清α-Klotho与男性AVC有关。Objective To study the relationship between serum fibroblast growth factor 23(FGF23)/α-Klotho levels and coronary artery calcification(CAC)and aortic valve calcification(AVC)in different genders patients.Methods One hundred and fifty-seven patients with diagnosed or suspected coronary artery disease(CAD)due to chest pain were selected.CAC and AVC were estimated by the agatston score of 128-detector computed tomography images,and serum FGF23 andα-Klotho levels were measured by enzyme-linked immunosorbent assay.Logistic regression analysis was used to analyze the correlation between FGF23,α-Klotho and CAC,and AVC.Results CAC and AVC were used as dependent variables for Logistic regression analysis,the highest FGF23(52.5,180.3)pg/mL was significantly positively associated with CAC in female patients after the adjustment for potential confounding variables including age,renal function,hypertension,statin use,diuretic use,and calcium/phosphate metabolism related factors(P<0.05).In addition,theα-Klotho(561,4859)pg/mL was significantly associated with AVC in male after adjusting for the same variables(P<0.05).The association between FGF23 and CAC/AVC in male or that betweenα-Klotho and CAC/AVC in female was nonsignificant.Conslusion Among subjects with diagnosed or suspected CAD,serum FGF23 was positively associated with CAC in female and serumα-Klotho was positively associated with AVC in male.

关 键 词：冠状动脉钙化 主动脉瓣钙化 纤维细胞生长因子23 α-Klotho 影响因素 

分 类 号：R541.4[医药卫生—心血管疾病]