载脂蛋白A1及其模拟肽的功能及与视网膜疾病关系的研究进展  

Research progress on function of apolipoprotein A1 and its mimetic peptides and the relationship with retinal diseases

作　　者：陈珠婷(综述) 胡洁(审校)[1] 胡安娣娜(审校) CHEN Zhuting;HU Jie;HU Andina(State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou 510060,China)

机构地区：[1]中山大学中山眼科中心,眼科国家重点实验室,广州510060

出　　处：《眼科学报》2020年第6期429-435,共7页Eye Science

基　　金：国家自然科学基金(81500735,81970807);广东省自然科学基金(2017A030313494)。

摘　　要：视网膜疾病的发病机制错综复杂,涉及氧化应激、病理性血管生成以及脂质沉积等。载脂蛋白A1(apolipoprotein A1,apoA1)及其模拟肽具有抗炎、抗氧化、逆向转运脂质及调节血管生成等功能。而动物实验及人体试验均证实了模拟肽D-4F口服使用的安全性及有效性,因此目前研究最为广泛。近年研究发现,apoA1及其模拟肽与糖尿病视网膜病变、年龄相关性黄斑变性等多种视网膜疾病密切相关,本文从apoA1及其模拟肽的分子结构、产生与分布、主要生理功能、及其在视网膜疾病研究中的最新进展进行了综述。The pathogenesis of retinal diseases is complex,involving with oxidative stress,pathological angiogenesis and lipid deposition.Apolipoprotein A1(apoA1)and its mimetic peptides have anti-inflammatory,antioxidant,reverse lipid transport and angiogenesis regulation functions.The safety and effectiveness of oral use of mimetic peptide D-4F have been confirmed in both animal and human studies.Therefore,D-4F is the most widely studied at present.In recent years,apoA1 and its mimetic peptides are closely related with diabetic retinopathy,age-related macular degeneration and other retinal diseases.In this article,the molecular structure,production and distribution,main physiological functions of apoA1 and its mimetic peptides,as well as the latest progress on the relationship with retinal diseases were reviewed.

关 键 词：载脂蛋白A1 模拟肽 视网膜疾病 脂质逆转运 抗炎 

分 类 号：R58[医药卫生—内分泌]