左卡尼汀口服液联合辅酶Q10治疗弱精子症患者的疗效及对IVF相关参数的影响分析  

Efficacy of Levocarnitine Oral Liquid Combined with Coenzyme Q10 in the Treatment of Asthenospermia Patients and Analysis of the Impact on IVF Related Parameters

作　　者：张明亮[1] 薛洁[1] 郑小挺 马玲 熊奇 熊涌[1] 杨敏 ZHANG Ming-liang;XUE Jie;ZHENG Xiao-ting;MA Ling;XIONG Qi;XIONG Yong;YANG Min(Affiliated Hospital of Nanchang Institute of Medical Sciences,Nanchang 330001,China)

机构地区：[1]南昌市医学科学研究所附属医院,江西南昌330001

出　　处：《现代诊断与治疗》2020年第22期3529-3532,共4页Modern Diagnosis and Treatment

摘　　要：目的探讨左卡尼汀口服液联合辅酶Q10治疗弱精子症患者的临床疗效,分析对IVF受精率和胚胎质量的影响。方法选择2019年1~8月我院生殖男科门诊收治的因弱精子症行IVF助孕的患者81例,按照随机分组的方法分为观察组41例和对照组40例。观察组采用左卡尼汀口服液联合辅酶Q10干预治疗,对照组单独采用辅酶Q10干预治疗,比较两组患者治疗后精液质量变化及临床有效率,分析两组IVF助孕后临床优质胚胎率。结果观察组治疗总有效率为90.0%,高于对照组的75.6%,差异有统计学意义(P<0.05);治疗后,观察组精子前向运动活动率和精子总活动率均高于对照组,观察组DFI情况显著低于对照组,差异均有统计学意义(P<0.05);观察组IVF受精数和临床优质胚胎数量均显著多于对照组,差异均有统计学意义(P<0.05)。结论左卡尼汀口服液联合辅酶Q10能明显改善弱精子症患者的精子质量,同时能提高其IVF临床的受精率及优质胚胎率。Objective To explore the clinical efficacy of L-carnitine oral liquid combined with coenzyme Q10 in the treatment of asthenospermia patients,and analyze the impact on IVF fertilization rate and embryo quality.Methods 81 patients,who were undergoing IVF for asthenospermiain our hospital's reproductive andrology clinic from January 2019 to August 2019,were selected and divided into observation group and control group by the random grouping method.The 41 patients in observation group were treated with levocarnitine oral liquid combined with coenzyme Q10,and 40 patients in the control group were treated with coenzyme Q10 alone.After treatment,the semen quality changes and clinical effective rates of the two groups were compared,and the clinical high-quality embryo rates after IVF were analyzed.Results The total effective rate of treatment in the observation group was 90.0%,which was higher than 75.6%in the control group,and the difference was statistically significant(P<0.05);After treatment,the forward sperm motility rate and total sperm motility rate of the observation group were higher than those in the control group.The DFI of the observation group was significantly lower than that of the control group,and the differences were statistically significant(P<0.05);The number of IVF fertilization and clinical quality embryos in the observation group were significantly more than those of the control group,and the differences were statistically significant(P<0.05).Conclusion Levocarnitine oral liquid combined with coenzyme Q10 could significantly improve the sperm quality of patients with asthenospermia,and improve their IVF clinical fertilization rate and high-quality embryo rate.

关 键 词：左卡尼汀口服液 辅酶Q10 弱精子症 IVF 

分 类 号：R698.2[医药卫生—泌尿科学]