丙酚替诺福韦用于范科尼综合征恩替卡韦治疗失败的慢性乙型肝炎患者挽救治疗:个案报道并文献复习  

Tenofovir alafenamide as the rescue therapy for chronic hepatitis B patient with Fanconi syndrome and entecavir treatment failure:a case report and literature review

作　　者：王倩[1] 常春艳 杨松[2] Wang Qian;Chang Chunyan;Yang Song(Department of Pharmacy,the 960th Hospital of PLA Joint Service Support Force,Jinan 250031,China;Center of Hepatology,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)

机构地区：[1]中国人民解放军联勤保障部队第960医院药学部,济南250031 [2]首都医科大学附属北京地坛医院肝病中心,北京100015

出　　处：《中国医学前沿杂志（电子版）》2021年第1期123-126,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：传染病防治国家科技重大专项(2017ZX10202202,2018ZX10715-005);吴阶平医学基金会临床科研专项(No.LDWJPMF-105-201701)。

摘　　要：慢性乙型肝炎治疗的关键是抗病毒治疗。临床上长期使用阿德福韦酯或富马酸替诺福韦二吡呋酯抗病毒治疗的慢性乙型肝炎患者可发生范科尼综合征等罕见不良反应,临床上多采用恩替卡韦作为挽救治疗方案。但对于恩替卡韦治疗失败的范科尼综合征患者,后续抗病毒治疗的证据尚不多见。现报道1例恩替卡韦治疗失败的范科尼综合征患者,采用丙酚替诺福韦治疗有效,并对相关文献进行复习,为此类患者的治疗提供依据。Antiviral therapy is the key for management of chronic hepatitis B.Fanconi syndrome is a rare side effect in chronic hepatitis B patients who take long-term therapy of adefovir dipivoxil or tenofovir disoproxil fumarate.Usually entecavir is chosen as rescue therapy for these patients.There is little evidence for rescue therapy for chronic hepatitis B patients who comorbid with Fanconi syndrome and experienced entecavir treatment failure.We reported a case of Fanconi syndrome patient who underwent entecavir treatment failure and was rescued successfully with tenofovir alafenamide.Also,we reviewed related literatures.Our case might provide evidence for management of chronic hepatitis B patients who experienced entecavir treatment failure and comorbid with Fanconi syndrome.

关 键 词：慢性乙型肝炎 丙酚替诺福韦 恩替卡韦 范科尼综合征 病毒学突破 

分 类 号：R512.62[医药卫生—内科学]