药物三联法治疗妊娠期高血压对分娩结局、母婴结局及D-二聚体与脂联素水平的影响  

Effects of triple medication therapy for gestational hypertension on delivery outcome,maternal and infant outcomes,D-dimer and adiponectin levels

作　　者：冯六连[1] 李儒佑[2] FENG Liu-lian;LI Ru-you(Department of Obstetrics,Edong Healthcare Group Huangshi Central Hospital,Huangshi 435000,China;Department of Respiratory Medicine,Edong Healthcare Group Huangshi Central Hospital,Huangshi 435000,China)

机构地区：[1]湖北省鄂东医疗集团黄石市中心医院产科,黄石市435000 [2]湖北省鄂东医疗集团黄石市中心医院呼吸内科,黄石市435000

出　　处：《广西医学》2020年第23期3064-3067,共4页Guangxi Medical Journal

摘　　要：目的探讨硫酸镁、拉贝洛尔联合尼莫地平的药物三联法治疗妊娠期高血压对分娩结局、母婴结局及血清D-二聚体与脂联素水平的影响。方法将180例妊娠期高血压孕妇随机分为试验组和对照组,各90例。在常规治疗的基础上,试验组加用硫酸镁、拉贝洛尔联合尼莫地平的药物三联法治疗,对照组仅加用硫酸镁治疗,记录两组孕妇的分娩结局、母婴结局,比较治疗前后两组孕妇的血清D-二聚体与脂联素水平。结果相比于对照组,试验组患者的自然分娩率升高,剖宫产率、产后出血率、宫缩乏力发生率、胎儿窘迫发生率、新生儿窒息发生率降低(P<0.05)。治疗后,试验组患者的D-二聚体水平低于对照组,而脂联素水平高于对照组(P<0.05)。结论硫酸镁、拉贝洛尔联合尼莫地平的药物三联法治疗妊娠期高血压,可有效改善分娩结局、母婴结局及血清D-二聚体和脂联素水平。Objective To investigate the effects of triple medication therapy of magnesium sulfate,labetalol combined with nimodipine for gestational hypertension on delivery outcome,maternal and infant outcomes,serum D-dimer and adiponectin levels.Methods A total of 180 pregnant women with gestational hypertension were randomly divided into experimental group(n=90)and control group(n=90).On the basis of conventional treatment,the experimental group underwent additional triple medication therapy of magnesium sulfate,labetalol combined with nimodipine,the control group only received additional magnesium sulfate.Delivery outcome and maternal and infant outcomes of pregnant women were recorded in both groups,and serum D-dimer and adiponectin levels of pregnant women were compared between the two groups before and after treatment.Results Compared with the control group,the experimental group exhibited elevated rate of natural delivery,decreased rates of cesarean section and postpartum hemorrhage,and lower incidence rates of uterine inertia,fetal distress and neonatal asphyxia(P<0.05).After treatment,the level of D-dimer was lower and the level of adiponectin was higher in the experimental group than in the control group(P<0.05).Conclusion Triple medication therapy of magnesium sulfate,labetalol and nimodipine for gestational hypertension can effectively improve delivery outcome,maternal and infant outcomes and serum D-dimer and adiponectin levels.

关 键 词：妊娠期高血压 硫酸镁 拉贝洛尔 尼莫地平 D-二聚体 脂联素 分娩结局 母婴结局 

分 类 号：R714.246[医药卫生—妇产科学]