艾司唑仑联合心神宁片治疗慢性失眠对患者认知功能的影响  

Effect of Estazolam Combined with Xinshenning Tablets on Cognitive Function in Patients with Chronic Insomnia

作　　者：陈骁勇 CHEN Xiaoyong(Department of Pharmacy,Yancheng No.1 People′s Hospital,Yancheng 224000,China)

机构地区：[1]江苏省盐城市第一人民医院药剂科,盐城224000

出　　处：《世界睡眠医学杂志》2020年第11期1880-1881,共2页World Journal of Sleep Medicine

摘　　要：目的:研究慢性失眠患者通过艾司唑仑结合心神宁片治疗的效果及对患者认知功能的影响。方法:选取2019年1月至2020年1月江苏省盐城市第一人民医院收治的慢性失眠患者60例作为研究对象,按照随机数字表法分为对照组和观察组,每组30例,对照组采用单纯艾司唑仑治疗,观察组采用心神宁片结合艾司唑仑治疗,分析2组患者的睡眠质量与认知功能。结果:与对照组比较,观察组慢性失眠患者给药4周末、8周末的PSQI评分更低(P<0.05)。2组患者给药前МoСА评分差异无统计学意义(P>0.05);与对照组比较,观察组慢性失眠患者给药后的МoСА评分更高(P<0.05)。结论:心神宁片结合艾司唑仑治疗对于改善睡眠质量,提高认知功能等有重要的意义。Objective:To study the effect of estazolam combined with Xinshenning tablets in the treatment of chronic insomnia and its influence on cognitive function.Methods:A total of 60 patients with chronic insomnia admitted to our hospital from January 2019 to January 2020 were randomly divided into control group(30 cases,treated with estazolam only)and observation group(30 cases treated with Xinshenning tablets combined with estazolam)according to the double-blind random method.The sleep quality and cognitive function of the patients were compared.Results:There was no significant difference in PSQI score between the two groups before administration(P>0.05).Compared with the control group,the PSQI score of chronic insomnia patients in the observation group was lower at the end of 4 and 8 weeks(P<0.05).There was no significant difference in theМoСАscore of the two groups before administration(P>0.05).Compared with the control group,theМoСАscore of patients with chronic insomnia in the observation group was higher(P<0.05).Conclusion:Xinshenning tablets combined with estazolam is of great significance in improving sleep quality and cognitive function.

关 键 词：慢性失眠 认知功能 心神宁片 疗效 艾司唑仑 

分 类 号：R338.63[医药卫生—人体生理学]