补肾活血法联合芬吗通治疗流产后宫腔粘连疗效及对血清FN、LN、VEGF水平的影响  

Effect of Kidney-Tonifying and Blood-Activating Method Combined with Fenmoton on Intrauterine Adhesion after Miscarriage and Its Effect on Serum Levels of FN, LN and VEGF

作　　者：向英[1] 周忠明[1] XIANG Ying;ZHOU Zhongming(Department of Gynecology and Obstetrics,Hubei Hospital of Traditional Chinese Medicine,Wuhan 430000,Hubei,China)

机构地区：[1]湖北省中医院妇产科,湖北武汉430000

出　　处：《中华中医药学刊》2020年第12期191-195,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：湖北省科技计划(WJ2016-Y-23)。

摘　　要：目的探讨补肾活血法联合芬吗通治疗流产后宫腔粘连的疗效及对血清FN、LN、VEGF水平影响。方法选取100例流产后宫腔粘连患者,随机分为两组各50例。对照组患者给予芬吗通,实验组在对照组基础上给予补肾活血方。对比两组患者的临床疗效、临床症状消失时间、中医症候积分、AFS评分、子宫内膜厚度、阻力指数和搏动指数、血液流变学指标及FN、LN、VEGF水平变化。结果治疗后,实验组总有效率较高(P<0.05);两组患者治疗前中医症候积分差异无统计学意义(P>0.05);两组患者治疗后月经周期经量、月经色质、头晕耳鸣、腰膝酸软、小腹胀痛证候评分显著降低(P<0.05);并且实验组降低较多(P<0.05);两组患者治疗前AFS评分差异无统计学意义(P>0.05);两组患者治疗后宫腔粘连类型、粘连累及范围及月经模式评分和总分明显降低(P<0.05);并且实验组降低较多(P<0.05);两组患者治疗前子宫内膜厚度、阻力指数和搏动指数差异无统计学意义(P>0.05);两组患者子宫内膜厚度显著升高,阻力指数和搏动指数显著降低(P<0.05);并且实验组改善较多(P<0.05);两组患者治疗前血液流变学指标水平差异无统计学意义(P>0.05);两组患者治疗后全血低切黏度、全血高切黏度、血浆黏度水平显著降低(P<0.05);并且实验组降低较多(P<0.05);两组患者治疗前FN、LN、VEGF水平差异无统计学意义(P>0.05);两组患者治疗后FN、LN、VEGF水平明显升高(P<0.05);并且实验组升高较多(P<0.05)。结论采用补肾活血法联合芬吗通治疗流产后宫腔粘连具有较好的治疗效果,能够改善血清FN、LN、VEGF水平,安全性较高,值得在临床上推广应用。Objective To investigate the effect of kidney-tonifying and blood-activating therapy combined with Fenmoton in the treatment of intrauterine adhesion after abortion and the effect on serum levels of FN, LN and VEGF. Methods A total of 100 cases of post-abortion intrauterine adhesion patients were randomly divided into two groups, 50 cases in each. Patients in the control group were given Fenmoton while the experimental group was given kidney-tonifying and blood-activating therapy on the basis of the control group. The clinical efficacy, clinical symptom disappearance time, TCM symptom score, AFS score, endometrial thickness, resistance index and pulsation index, hemorheology index and levels of FN, LN and VEGF in the two groups were compared. Results After treatment, the total effective rate of the experimental group was higher(P<0.05). There was no difference in TCM syndrome score between the two groups before treatment(P>0.05). After treatment, menstrual cycle volume, menstrual color quality, dizziness and tinnitus, lumbar and knee tenderness, and abdominal distension syndrome score of patients in the two groups significantly decreased(P<0.05). And those of the experimental group decreased significantly(P<0.05). There was no difference in AFS scores between the two groups before treatment(P>0.05). After treatment, the types, range, menstrual pattern score and total score of intrauterine adhesions in the two groups were significantly decreased(P<0.05). And those of the experimental group decreased significantly(P<0.05). There was no difference in endometrial thickness, resistance index and beat index between the two groups before treatment(P>0.05). The endometrial thickness of the two groups increased significantly, and the resistance index and beat index decreased significantly(P<0.05). And those of the experimental group improved a lot(P<0.05). There was no difference in hemorheology before treatment between the two groups(P>0.05). After treatment, the levels of low viscosity, high viscosity and plasma viscosi

关 键 词：补肾活血法 芬吗通 流产后宫腔粘连 血清FN、LN、VEGF水平 

分 类 号：R271.43[医药卫生—中医妇科学] R271.914.21[医药卫生—中医学]